Separation of antifungal chiral drugs by SFC and HPLC: a comparative study

被引：47

作者：

Bernal, JL

Toribio, L

del Nozal, MJ

Nieto, EM

Montequi, MI

机构：

[1] Univ Valladolid, Fac Sci, Dept Analyt Chem, E-47005 Valladolid, Spain

[2] Univ Valladolid, Fac Sci, Dept Chem Phys, E-47005 Valladolid, Spain

来源：

JOURNAL OF BIOCHEMICAL AND BIOPHYSICAL METHODS | 2002年 / 54卷 / 1-3期

关键词：

chiral SFC; chiral HPLC; ketoconazole; chiralpak AD; chiralcel OD;

D O I：

10.1016/S0165-022X(02)00119-7

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The enantiomeric separation of several compounds, including an antifungal drug and several of its precursors, using HPLC and SFC is described in this work. The columns employed were based on polysaccharide derivatives and the results show that most of the separations obtained by SFC are better, in terms of high resolution and short analysis time, than those obtained by HPLC. Only one compound could not be resolved using SFC but, in this case, HPLC provided baseline resolution. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：245 / 254

页数：10

共 17 条

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[2]

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