Isolation and syntheses of polymethoxyflavones and hydroxylated polymethoxyflavones as inhibitors of HL-60 cell lines

被引：160

作者：

Li, Shiming

Pan, Min-Hsiung

Lai, Ching-Shu

Lo, Chih-Yu

Dushenkov, Slavik

Ho, Chi-Tang

机构：

[1] Rutgers State Univ, Dept Food Sci, New Brunswick, NJ 08901 USA

[2] Natl Kaohsiung Marine Univ, Dept Seafood Sci, Kaohsiung, Taiwan

[3] WellGen Inc, New Brunswick, NJ 08901 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2007年 / 15卷 / 10期

关键词：

5-demethylnobiletin; 5-hydroxy-3,6,7,8,3 ',4 '-hexamethoxyflavone; PMF synthesis; HL-60 cell lines;

D O I：

10.1016/j.bmc.2007.03.021

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Fifteen polymethoxyflavones (PMFs) and hydroxylated PMFs were isolated from sweet orange (Citrus sinensis) peel extract and synthesized to investigate their biological activity. All obtained compounds were tested in HL-60 cancer cell proliferation and apoptosis induction assays. While some PMFs and hydroxylated PMFs had moderate anti-carcinogenic activities, 5-hydroxy-6,7,8,3',4'-pentamethoxyflavone and 5-hydroxy- 3,6,7,8,3',4'-hexamethoxyflavone showed strong inhibitory activities against the proliferation and induced apoptosis of HL-60 cell lines. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：3381 / 3389

页数：9

共 23 条

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