Restricting expression prolongs expression of foreign genes introduced into animals by retroviruses

被引：13

作者：

Pinto, VB

Prasad, S

Yewdell, J

Bennink, J

Hughes, SH

机构：

[1] NCI, Frederick Canc Res & Dev Ctr, ABL Basic Res Program, Frederick, MD 21702 USA

[2] NIAID, Viral Dis Lab, NIH, Bethesda, MD 20892 USA

来源：

JOURNAL OF VIROLOGY | 2000年 / 74卷 / 21期

关键词：

D O I：

10.1128/JVI.74.21.10202-10206.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

If foreign genes are ubiquitously expressed in mice using a viral vector, expression is abrogated by CD8(+) cells in 2 to 4 weeks. However, if the expression of the genes is confined to skeletal muscle cells, the CD8(+) T-cell response is much weaker and expression is maintained for more than 6 weeks. These data show that restricting the expression of foreign genes to skeletal muscle cells and presumably to other cells that are inefficient at antigen presentation can prolong the expression of a foreign gene product.

引用

收藏

页码：10202 / 10206

页数：5

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