Surface plasmon resonance interferometry for micro-array biosensing

被引:115
作者
Nikitin, PI
Grigorenko, AN
Beloglazov, AA
Valeiko, MV
Savchuk, AI
Savchuk, OA
Steiner, G
Kuhne, C
Huebner, A
Salzer, R
机构
[1] Russian Acad Sci, Inst Gen Phys, Moscow 117942, Russia
[2] Chernivtsi Univ, UA-274012 Chernivtsi, Ukraine
[3] Dresden Univ Technol, Inst Analyt Chem, D-01062 Dresden, Germany
基金
俄罗斯基础研究基金会;
关键词
array; biosensors; surface plasmon resonance; interferometer; phase;
D O I
10.1016/S0924-4247(00)00386-1
中图分类号
TM [电工技术]; TN [电子技术、通信技术];
学科分类号
0808 ; 0809 ;
摘要
Interferometry that detects the phase of a beam reflected under surface plasmon resonance (SPR) has been developed for bio and chemical sensing. The conditions have been found, under which the phase reveals abrupt jumps in response to a minute increase in the effective thickness of a receptor layer that binds analyte particles on the sensor surface. This forms the basis for biosensing with sensitivity much higher as compared to traditional SPR sensors. Besides, SPR interferometry (SPRI) provides spatial resolution at the micron scale. The enhanced sensitivity attributed to the phase jump and interferometric imaging of variations of the phase over the surface are demonstrated, which open up new avenues for micro-array biosensing. (C) 2000 Elsevier Science S.A. All rights reserved.
引用
收藏
页码:189 / 193
页数:5
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