Asymmetric synthesis of tetrahydrofurans and tetrahydropyrans with competitive [1,2]-phenylsulfanyl (PhS) migration (II): synthesis of protected tetrahydropyrans

被引：7

作者：

Fox, DJ

House, D

Kerr, F

Warren, S

机构：

[1] Univ Cambridge, Chem Lab, Cambridge CB2 1EW, England

[2] AstraZeneca R&D Sodertalje, Proc R&D, S-15185 Sodertalje, Sweden

来源：

CHEMICAL COMMUNICATIONS | 2000年 / 18期

关键词：

D O I：

10.1039/b005341o

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Enantiomerically enriched triols were treated with trimethylorthoacetate and pyridinium toluene p-sulfonate to give a mixture of unrearranged THF and rearranged THP; treatment of the product mixture with toluene p-sulfonic acid equilibrated the mixture to the THP.

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页码：1781 / 1782

页数：2

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