Immunization with Porphyromonas gingivalis capsular polysaccharide prevents P-gingivalis-elicited oral bone loss in a murine model

被引：42

作者：

Gonzalez, D

Tzianabos, AO

Genco, CA

Gibson, FC

机构：

[1] Boston Univ, Med Ctr, Evans Biomed Res Ctr, Boston, MA 02118 USA

[2] Boston Univ, Med Ctr, Goldman Sch Dent Med, Dept Periodontol & Oral Biol, Boston, MA 02118 USA

[3] Boston Univ, Med Ctr, Infect Dis Sect, Dept Med, Boston, MA 02118 USA

[4] Boston Univ, Med Ctr, Dept Microbiol, Boston, MA 02118 USA

[5] Harvard Univ, Brigham & Womens Hosp, Sch Med, Channing Lab, Boston, MA 02115 USA

来源：

INFECTION AND IMMUNITY | 2003年 / 71卷 / 04期

关键词：

D O I：

10.1128/IAI.71.4.2283-2287.2003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The capsular polysaccharide (CPS) of the periodontal pathogen Porphyromonas gingivalis is an important virulence factor for this organism. We purified P. gingivalis CPS, immunized mice with this antigen, and assessed the vaccine potential of P. gingivalis CPS by using the murine oral challenge model. Animals immunized with P. gingivalis CPS developed elevated levels of immunoglobulin M (IgM) and IgG in serum that reacted with whole P. gingivalis organisms. The mice immunized with P. gingivalis CPS were protected from P. gingivalis-elicited oral bone loss. These data demonstrate that P. gingivalis CPS is a vaccine candidate for prevention of P. gingivalis-elicited oral bone loss.

引用

收藏

页码：2283 / 2287

页数：5

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