A tyrosine-to-threonine mutation converts cycloartenol synthase to an oxidosqualene cyclase that forms lanosterol as its major product

被引:53
作者
Herrera, JBR
Wilson, WK
Matsuda, SPT [1 ]
机构
[1] Rice Univ, Dept Chem, Houston, TX 77005 USA
[2] Rice Univ, Dept Biochem & Cell Biol, Houston, TX 77005 USA
关键词
D O I
10.1021/ja0013226
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
引用
收藏
页码:6765 / 6766
页数:2
相关论文
共 23 条
[1]   BIOSYNTHETIC-STUDIES OF MARINE LIPIDS .25. BIOSYNTHESIS OF DELTA-9(11)-STEROLS AND DELTA-7-STEROLS AND SAPONINS IN SEA-CUCUMBERS [J].
CORDEIRO, ML ;
DJERASSI, C .
JOURNAL OF ORGANIC CHEMISTRY, 1990, 55 (09) :2806-2813
[2]   ISOLATION OF AN ARABIDOPSIS-THALIANA GENE ENCODING CYCLOARTENOL SYNTHASE BY FUNCTIONAL EXPRESSION IN A YEAST MUTANT LACKING LANOSTEROL SYNTHASE BY THE USE OF A CHROMATOGRAPHIC SCREEN [J].
COREY, EJ ;
MATSUDA, SPT ;
BARTEL, B .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (24) :11628-11632
[3]   Molecular cloning of a Schizosaccharomyces pombe cDNA encoding lanosterol synthase and investigation of conserved tryptophan residues [J].
Corey, EJ ;
Matsuda, SPT ;
Baker, CH ;
Ting, AY ;
Cheng, HM .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1996, 219 (02) :327-331
[4]   Cation-pi interactions in chemistry and biology: A new view of benzene, Phe, Tyr, and Trp [J].
Dougherty, DA .
SCIENCE, 1996, 271 (5246) :163-168
[5]   H-1 AND C-13 NMR ASSIGNMENTS FOR LANOSTAN-3 BETA-OL DERIVATIVES - REVISED ASSIGNMENTS FOR LANOSTEROL [J].
EMMONS, GT ;
WILSON, WK ;
SCHROEPFER, GJ .
MAGNETIC RESONANCE IN CHEMISTRY, 1989, 27 (11) :1012-1024
[6]   Cloning and characterization of the Dictyostelium discoideum cycloartenol synthase cDNA [J].
Godzina, SM ;
Lovato, MA ;
Meyer, MM ;
Foster, KA ;
Wilson, WK ;
Gu, W ;
de Hostos, EL ;
Matsuda, SPT .
LIPIDS, 2000, 35 (03) :249-255
[7]   Directed evolution to investigate steric control of enzymatic oxidosqualene cyclization. An isoleucine-to-valine mutation in cycloartenol synthase allows lanosterol and parkeol biosynthesis [J].
Hart, EA ;
Hua, L ;
Darr, LB ;
Wilson, WK ;
Pang, JH ;
Matsuda, SPT .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (42) :9887-9888
[8]  
Hayashi H., 1999, Plant Physiology, V121, P1384
[9]  
Hayashi H, 2000, BIOL PHARM BULL, V23, P231, DOI 10.1248/bpb.23.231
[10]  
Herrera JBR, 1998, PHYTOCHEMISTRY, V49, P1905, DOI 10.1016/S0031-9422(98)00366-5