Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm

被引：634

作者：

Newton, AC ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA

来源：

BIOCHEMICAL JOURNAL | 2003年 / 370卷 / 02期

关键词：

phosphoinositide; 3-kinase; phosphoinositide-dependent kinase-1 (PDK-1); phosphorylation motif; protein kinase A (PKA); protein kinase B (PKB)/Akt; protein kinase C (PKC);

D O I：

10.1042/BJ20021626

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phosphorylation plays a central role in regulating the activation and signalling lifetime of protein kinases A, B (also known as Akt) and C. These kinases share three conserved phosphorylation motifs: the activation loop segment, the turn motif and the hydrophobic motif. This review focuses on how phosphorylation at each of these sites regulates the maturation, signalling and down-regulation of PKC as a paradigm for how these sites control the function of the ABC kinases.

引用

页码：361 / 371

页数：11

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