Evaluating symptoms in chronic obstructive pulmonary disease:: validation of the Breathlessness, Cough and Sputum Scale©

被引:39
作者
Leidy, NK
Schmier, JK
Jones, MKC
Lloyd, J
Rocchiccioli, K
机构
[1] MEDTAP Int, Ctr Hlth Outcomes Res, Bethesda, MD 20814 USA
[2] AstraZeneca R&D Charnwood, Loughborough, Leics, England
[3] AstraZeneca Pharmaceut LP, Wilmington, DE USA
关键词
symptoms; COPD; assessment; bronchitis; emphysema; psychometric validation; patient-reported outcome measure;
D O I
10.1016/S0954-6111(03)80016-1
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
This study examined the reliability and validity of a new measure for evaluating symptoms in patients with chronic obstructive pulmonary disease (COPD): the Breathlessness, Cough and Sputum Scale (BCSS(R)). Designed as a daily diary, the BCSS is a patient-reported outcome measure that asks patients to rate the severity of the three symptoms, each on a 5-point scale: higher scores indicate more severe symptoms, Item scores are summed to yield a total score. Secondary analysis of data were from two multinational trials (n=629; 765). The BCSS item and total scores exhibited evidence of internal consistency (alpha = 0(.)70 daily; 0(.)95 to 0(.)99 over time) and reproducibility (ICC = 0(.)77 to 0(.)88), Correlations (r) with pulmonary function (FEV1 % predicted, PEF) were-0(.)01 (n.s.) to -0(.)36 (P < 0(.)001). Correlations with the St George's Respiratory Questionnaire total and SF-36 Physical Functioning subscale were 0(.)44 to 0(.)59 (P < 0(.)001). Breathlessness and total scores differentiated patients by disease severity (P < 0(.)01) and rescue medication use (P < 0(.)01). Cough, sputum, and total scores increased with sputum volume (r=0(.)27, 0(.)30, 0(.)31; P < 0(.)001), Patients for whom treatment was moderately or highly effective reported significant improvements in BCSS scores (P < 0(.)0001). Results suggest that the BCSS is a reliable, valid, and responsive patient-reported outcome measure of symptom severity in patients with COPD. (C) 2003 Elsevier Science Ltd.
引用
收藏
页码:S59 / S70
页数:12
相关论文
共 41 条
[1]   Testing the measurement properties of the Spanish version of the SF-36 Health Survey among male patients with chronic obstructive pulmonary disease [J].
Alonso, J ;
Prieto, L ;
Ferrer, M ;
Vilagut, G ;
Broquetas, JM ;
Roca, J ;
Batlle, JS ;
Antó, JM .
JOURNAL OF CLINICAL EPIDEMIOLOGY, 1998, 51 (11) :1087-1094
[2]   LUNG-FUNCTION TESTING - SELECTION OF REFERENCE VALUES AND INTERPRETATIVE STRATEGIES [J].
不详 .
AMERICAN REVIEW OF RESPIRATORY DISEASE, 1991, 144 (05) :1202-1218
[3]   Usefulness of the Medical Research Council (MRC) dyspnoea scale as a measure of disability in patients with chronic obstructive pulmonary disease [J].
Bestall, JC ;
Paul, EA ;
Garrod, R ;
Garnham, R ;
Jones, PW ;
Wedzicha, JA .
THORAX, 1999, 54 (07) :581-586
[4]   PSYCHOPHYSICAL BASES OF PERCEIVED EXERTION [J].
BORG, GAV .
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 1982, 14 (05) :377-381
[5]  
Cohen J., 1998, Statistical Power Analysis for the Behavioral Sciences, V2nd
[6]   Effects of psychotherapy in moderately severe COPD: A pilot study [J].
Eiser, N ;
West, C ;
Evans, S ;
Jeffers, A ;
Quirk, F .
EUROPEAN RESPIRATORY JOURNAL, 1997, 10 (07) :1581-1584
[7]   Relationship between chronic dyspnea and expiratory flow limitation in patients with chronic obstructive pulmonary disease [J].
Eltayara, L ;
Becklake, MR ;
Volta, CA ;
MilicEmili, J .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1996, 154 (06) :1726-1734
[8]  
Espada R, 1999, CHEST, V116, P1750
[9]   Validity and reliability of the St George's Respiratory Questionnaire after adaptation to a different language and culture: The Spanish example [J].
Ferrer, M ;
Alonso, J ;
Prieto, L ;
Plaza, V ;
Monso, E ;
Marrades, R ;
Aguar, MC ;
Khalaf, A ;
Anto, JM .
EUROPEAN RESPIRATORY JOURNAL, 1996, 9 (06) :1160-1166
[10]   Quality of life assessment after patient education in a randomized controlled study on asthma and chronic obstructive pulmonary disease [J].
Gallefoss, F ;
Bakke, PS ;
Kjærsgaard, P .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1999, 159 (03) :812-817