Resolution of the diastereomers of a large synthetic peptide by capillary electrophoresis using nonionic surfactants

被引：7

作者：

Gilges, M ^{[1
]}

Hadley, M ^{[1
]}

机构：

[1] SmithKline Beecham Pharmaceut, Dept Analyt Sci, Tonbridge TN11 9AN, Kent, England

来源：

ELECTROPHORESIS | 1997年 / 18卷 / 15期

关键词：

capillary electrophoresis; Brij; 35; nonionic surfactant; diastereomers; bradykinin;

D O I：

10.1002/elps.1150181536

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

a capillary electrophoretic method was developed for the determination of the diastereomeric composition of the bradykinin B-2 antagonist, SE-238592-DB. The nonionic surfactant Brij 35 was demonstrated to be suitable for the baseline resolution of the three diastereoisomers of SE-238592-DB in the presence of a low pH phosphate buffer and small volume percentages of acetonitrile.

引用

页码：2944 / 2949

页数：6

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