Vanadium-mediated oxidation of NADH is enhanced by aluminium and inhibited by vitamin E and some copper (II) complexes

The effect of aluminium on vanadium-mediated oxidation of NADH was examined. The oxidation of NADH was enhanced in the presence of aluminium. The effect was concentration dependent. Vitamin E and copper (II) complexes with superoxide dismutase (COD)-like activities containing isobutyric acid hydrazine were rested for their effect on the vanadium-mediated oxidation of NADH. The stimulatory effect of aluminium was decreased upon addition of different concentrations of vitamin E and copper (II) complexes. These results indicate that the biological toxicity of aluminium may be attributed to its enhancement of the production of superoxide radicals (O-2(.-)) in association with the accumulation of other trace elements such as vanadium.