Imaging of cholinergic and monoaminergic neurochemical changes in neurodegenerative disorders

被引：49

作者：

Bohnen, Nicolaas I.

Frey, Kirk A.

机构：

[1] Univ Hosp, Div Nucl Med, Dept Radiol, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Sch Med, Dept Radiol, Ann Arbor, MI 48109 USA

来源：

MOLECULAR IMAGING AND BIOLOGY | 2007年 / 9卷 / 04期

基金：

美国国家卫生研究院;

关键词：

Parkinson disease; Alzheimer disease; acetylcholine; dopamine; serotonin; norepinephrine; PET; SPECT;

D O I：

10.1007/s11307-007-0083-6

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Positron emission tomography (PET) or single photon emission computer tomography (SPECT) imaging provides the means to study neurochemical processes in vivo. These methods have been applied to examine monoaminergic and cholinergic changes in neurodegenerative disorders. These investigations have provided important insights into disorders, such as Alzheimer's disease (AD) and Parkinson's disease (PD). The most intensely studied monoaminergic transmitter is dopamine. The extent of presynaptic nigrostriatal dopaminergic denervation can be quantified in PD and may serve as a diagnostic biomarker. Dopaminergic receptor imaging may help to distinguish idiopathic PD from atypical parkinsonian disorders. Cholinergic denervation has been identified not only in AD but also in PD and more severely in parkinsonian dementia. PET or SPECT can also provide biomarkers to follow progression of disease or evaluate the effects of therapeutic interventions. Cholinergic receptor imaging is expected to play a major role in new drug development for dementing disorders.

引用

收藏

页码：243 / 257

页数：15

相关论文

共 181 条

[1] Measurement of striatal and extrastriatal dopamine D1 receptor binding potential with [11C]NNC 112 in humans:: Validation and reproducibility [J].

Abi-Dargham, A ;

Martinez, D ;

Mawlawi, O ;

Simpson, N ;

Hwang, DR ;

Slifstein, M ;

Anjilvel, S ;

Pidcock, J ;

Guo, NN ;

Lombardo, I ;

Mann, JJ ;

Van Heertum, R ;

Foged, C ;

Halldin, C ;

Laruelle, M .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2000, 20 (02) :225-243

[2] Complementary PET studies of striatal neuronal function in the differential diagnosis between multiple system atrophy and Parkinson's disease [J].

Antonini, A ;

Leenders, KL ;

Vontobel, P ;

Maguire, RP ;

Missimer, J ;

Psylla, M ;

Günther, I .

BRAIN, 1997, 120 :2187-2195

[3] DIFFERENTIAL ALTERATION OF VARIOUS CHOLINERGIC MARKERS IN CORTICAL AND SUBCORTICAL REGIONS OF HUMAN-BRAIN IN ALZHEIMERS-DISEASE [J].

ARAUJO, DM ;

LAPCHAK, PA ;

ROBITAILLE, Y ;

GAUTHIER, S ;

QUIRION, R .

JOURNAL OF NEUROCHEMISTRY, 1988, 50 (06) :1914-1923

[4] LOSS OF NEURONS IN THE NUCLEUS BASALIS OF MEYNERT IN ALZHEIMERS-DISEASE, PARALYSIS AGITANS AND KORSAKOFFS DISEASE [J].

ARENDT, T ;

BIGL, V ;

ARENDT, A ;

TENNSTEDT, A .

ACTA NEUROPATHOLOGICA, 1983, 61 (02) :101-108

[5] Brain muscarinic receptors in progressive supranuclear palsy and Parkinson's disease: a positron emission tomographic study [J].

Asahina, M ;

Suhara, T ;

Shinotoh, H ;

Inoue, O ;

Suzuki, K ;

Hattori, T .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1998, 65 (02) :155-163

[6]

ATACK JR, 1986, J NEUROCHEM, V47, P263

[7] COMPARATIVE ALTERATIONS OF NICOTINIC AND MUSCARINIC BINDING-SITES IN ALZHEIMERS AND PARKINSONS DISEASES [J].

AUBERT, I ;

ARAUJO, DM ;

CECYRE, D ;

ROBITAILLE, Y ;

GAUTHIER, S ;

QUIRION, R .

JOURNAL OF NEUROCHEMISTRY, 1992, 58 (02) :529-541

[8] EVIDENCE THAT TOBACCO SMOKING INCREASES THE DENSITY OF (-)-[H-3]NICOTINE BINDING-SITES IN HUMAN-BRAIN [J].

BENWELL, MEM ;

BALFOUR, DJK ;

ANDERSON, JM .

JOURNAL OF NEUROCHEMISTRY, 1988, 50 (04) :1243-1247

[9] Degree of inhibition of cortical acetylcholinesterase activity and cognitive effects by donepezil treatment in Alzheimer's disease [J].

Bohnen, NI ;

Kaufer, DI ;

Hendrickson, R ;

Ivanco, LS ;

Lopresti, BJ ;

Koeppe, RA ;

Meltzer, CC ;

Constantine, G ;

Davis, JG ;

Mathis, CA ;

DeKosky, ST ;

Moore, RY .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2005, 76 (03) :315-319

[10] Cognitive correlates of cortical cholinergic denervation in Parkinson's disease and parkinsonian dementia [J].

Bohnen, NI ;

Kaufer, DI ;

Hendrickson, R ;

Ivanco, LS ;

Lopresti, BJ ;

Constantine, GM ;

Mathis, CA ;

Davis, JG ;

Moore, RY ;

DeKosky, ST .

JOURNAL OF NEUROLOGY, 2006, 253 (02) :242-247

← 1 2 3 4 5 6 7 8 9 10 →