Imaging of cholinergic and monoaminergic neurochemical changes in neurodegenerative disorders

被引:49
作者
Bohnen, Nicolaas I.
Frey, Kirk A.
机构
[1] Univ Hosp, Div Nucl Med, Dept Radiol, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Sch Med, Dept Radiol, Ann Arbor, MI 48109 USA
基金
美国国家卫生研究院;
关键词
Parkinson disease; Alzheimer disease; acetylcholine; dopamine; serotonin; norepinephrine; PET; SPECT;
D O I
10.1007/s11307-007-0083-6
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Positron emission tomography (PET) or single photon emission computer tomography (SPECT) imaging provides the means to study neurochemical processes in vivo. These methods have been applied to examine monoaminergic and cholinergic changes in neurodegenerative disorders. These investigations have provided important insights into disorders, such as Alzheimer's disease (AD) and Parkinson's disease (PD). The most intensely studied monoaminergic transmitter is dopamine. The extent of presynaptic nigrostriatal dopaminergic denervation can be quantified in PD and may serve as a diagnostic biomarker. Dopaminergic receptor imaging may help to distinguish idiopathic PD from atypical parkinsonian disorders. Cholinergic denervation has been identified not only in AD but also in PD and more severely in parkinsonian dementia. PET or SPECT can also provide biomarkers to follow progression of disease or evaluate the effects of therapeutic interventions. Cholinergic receptor imaging is expected to play a major role in new drug development for dementing disorders.
引用
收藏
页码:243 / 257
页数:15
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