Typing TPMT and ITPase to detect azathioprine toxicity

被引：6

作者：

Arenas, Monica

Marinaki, Anthony

Ansari, Azhar

Sanderson, Jeremy

机构：

[1] St Thomas Hosp, Guys & St Thomas Hosp, Dept Gastroenterol, London SE1 7EH, England

[2] Guys Hosp, Purine Res Lab, London SE1 9RT, England

来源：

PERSONALIZED MEDICINE | 2006年 / 3卷 / 01期

关键词：

6-mercaptopurine; adverse effects; azathioprine; drug toxicity; inflammatory bowel disease; inosine triphosphatase; inosine triphosphate; pyrophosphohydrolase; ITPA; ITPase; thiopurine methyl transferase; thiopurine; TPMT;

D O I：

10.2217/17410541.3.1.45

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Genetic variation in thiopurine methyltransferase (TPMT) enzyme activity strongly predicts adverse effects in patients treated with the thiopurine drugs, azathioprine and 6-mercaptopurine, and is one of the classic examples of pharmacogenetics in clinical practice. Recently, polymorphic variation in the gene encoding the enzyme inosine triphosphatase (ITPase) has also been associated with risk of thiopurine-related toxicity. This article reviews the evidence for the role of TPMT and ITPase deficiency as predictors of thiopurine toxicity and makes recommendations for clinical and laboratory practice.

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收藏

页码：45 / 59

页数：15

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