Copper and Alzheimer's disease

被引：156

作者：

Donnelly, Paul S. ^{[1
]}

Xiao, Zhiguang

Wedd, Anthony G.

机构：

[1] Univ Melbourne, Sch Chem, Parkville, Vic 3052, Australia

[2] Bio21 Mol Sci & Biotechnol Inst, Parkville, Vic 3052, Australia

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2007年 / 11卷 / 02期

基金：

澳大利亚研究理事会;

关键词：

D O I：

10.1016/j.cbpa.2007.01.678

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Copper is essential for some of the enzymes that have a role in brain metabolism. Sophisticated mechanisms balance copper import and export to ensure proper nutrient levels (homeostasis) while minimizing toxic effects. Several neurodegenerative diseases including Alzheimer's disease (AD) are characterized by modified copper homeostasis. This change seems to contribute either directly or indirectly to increased oxidative stress, an important factor in neuronal toxicity. When coupled to misfolded proteins, this modified copper homeostasis appears to be an important factor in the pathological progression of AD.

引用

页码：128 / 133

页数：6

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