Chemical etiology of nucleic acid structure:: The α-threofuranosyl-(3′→2′) oligonucleotide system

被引：453

作者：

Schöning, KU

Scholz, P

Guntha, S

Wu, X

Krishnamurthy, R

Eschenmoser, A

机构：

[1] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

[2] Swiss Fed Inst Technol, Organ Chem Lab, CH-8092 Zurich, Switzerland

来源：

SCIENCE | 2000年 / 290卷 / 5495期

关键词：

D O I：

10.1126/science.290.5495.1347

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

TNAs [(L)-alpha -threofuranosyl oligonucleotides] containing vicinally connected (3'-->2') phosphodiester bridges undergo informational base pairing in antiparallel strand orientation and are capable of cross-pairing with RNA and DNA. Being derived from a sugar containing only four carbons, TNA is structurally the simplest of all potentially natural oligonucleotide-type nucleic acid alternatives studied thus far. This, along with the base-pairing properties of TNA, warrants close scrutiny of the system in the context of the problem of RNA's origin.

引用

页码：1347 / 1351

页数：5

共 48 条

[11] WHY PENTOSE AND NOT HEXOSE NUCLEIC-ACIDS .1. INTRODUCTION TO THE PROBLEM, CONFORMATIONAL-ANALYSIS OF OLIGONUCLEOTIDE SINGLE STRANDS CONTAINING 2',3'-DIDEOXYGLUCOPYRANOSYL BUILDING-BLOCKS (HOMO-DNA), AND REFLECTIONS ON THE CONFORMATION OF A-DNA AND B-DNA [J].