Regulation of human β-defensins by gastric epithelial cells in response to infection with Helicobacter pylori or stimulation with interleukin-1

被引：103

作者：

O'Neil, DA

Cole, SP

Martin-Porter, E

Housley, MP

Liu, L

Ganz, T

Kagnoff, MF

机构：

[1] Univ Calif San Diego, Dept Med 0623D, Lab Mucosal Immunol, La Jolla, CA 92093 USA

[2] Univ Calif Los Angeles, Dept Med, Will Rogers Pulm Res Lab, Los Angeles, CA 90095 USA

来源：

INFECTION AND IMMUNITY | 2000年 / 68卷 / 09期

关键词：

D O I：

10.1128/IAI.68.9.5412-5415.2000

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Gastric epithelial cells in vitro and in vivo are shown to constitutively express the peptide antibiotic human beta-defensin type 1 (hBD-1). In contrast, hBD-2 expression is regulated in gastric epithelial cells and increases in response to infection with Helicobacter pylori or stimulation with the proinflammatory cytokine interleukin-1. These data suggest that hBD-2 is a component of the regulated host gastric epithelial cell response to H. pylori infection and proinflammatory mediators.

引用

收藏

页码：5412 / 5415

页数：4

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