Prions: Portable prion domains

被引：19

作者：

Wickner, RB ^{[1
]}

Taylor, KL ^{[1
]}

Edskes, HK ^{[1
]}

Maddelein, ML ^{[1
]}

机构：

[1] NIDDK, Lab Biochem & Genet, NIH, Bethesda, MD 20892 USA

来源：

CURRENT BIOLOGY | 2000年 / 10卷 / 09期

关键词：

D O I：

10.1016/S0960-9822(00)00460-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Self-propagating abnormal proteins, prions, have been identified in yeast; asparagine/glutamine rich 'prion domains' within these proteins can inactivate the linked functional domains; new prion domains and reporters have been used to make 'synthetic prions', leading to discoveries of new natural prions.

引用

页码：R335 / R337

页数：3

共 36 条

[31] Prion domain initiation of amyloid formation in vitro from native Ure2p [J].

Taylor, KL ;

Cheng, NQ ;

Williams, RW ;

Steven, AC ;

Wickner, RB .

SCIENCE, 1999, 283 (5406) :1339-1343

[32]

TERAVANESYAN MD, 1994, GENETICS, V137, P671

[33] Molecular genetics of transmissible spongiform encephalopathies [J].

Weissmann, C .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (01) :3-6

[34] [URE3] AS AN ALTERED URE2 PROTEIN - EVIDENCE FOR A PRION ANALOG IN SACCHAROMYCES-CEREVISIAE [J].

WICKNER, RB .

SCIENCE, 1994, 264 (5158) :566-569

[35]

WICKNER RB, 1976, GENETICS, V82, P273

[36] TERMINATION OF TRANSLATION IN EUKARYOTES IS GOVERNED BY 2 INTERACTING POLYPEPTIDE-CHAIN RELEASE FACTORS, ERF1 AND ERF3 [J].

ZHOURAVLEVA, G ;

FROLOVA, L ;

LEGOFF, X ;

LEGUELLEC, R ;

INGEVECHTOMOV, S ;

KISSELEV, L ;

PHILIPPE, M .

EMBO JOURNAL, 1995, 14 (16) :4065-4072

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