Cyclo(Dehydroala-L-Leu), an α-glucosidase inhibitor from Penicillium sp F70614

被引：45

作者：

Kwon, OS

Park, SH

Yun, BS

Pyun, YR

Kim, CJ

机构：

[1] Korea Res Inst Biosci & Biotechnol, Taejon 305600, South Korea

[2] Korea Univ, Grad Sch Biotechnol, Seoul 136701, South Korea

[3] Yonsei Univ, Dept Biotechnol, Seoul 120749, South Korea

来源：

JOURNAL OF ANTIBIOTICS | 2000年 / 53卷 / 09期

关键词：

D O I：

10.7164/antibiotics.53.954

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A diketopiperazine (1) has been isolated from the culture broth of Penicillium sp. F70614 and its structure has been determined to be cyclo(dehydroala-L-Leu) by various spectroscopic analyses. This compound selectively inhibited yeast alpha-glucosidase and porcine intestinal alpha-glucosidase with IC50 values of 35 and 50 mu g/ml, respectively. However, it did not show significant inhibitory effects against almond beta-glucosidase, Aspergillus alpha-galactosidase, Escherichia coli beta-galactosidase and jack bean alpha-mannosidase.

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页码：954 / 958

页数：5

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