Phenylpropanoid NF-kB inhibitors from Bupleurum fruticosum

被引：29

作者：

Bremner, P

Tang, S

Birkmayer, H

Fiebich, BL

Muñoz, E

Marquez, N

Rivera, D

Heinrich, M

机构：

[1] Univ London Sch Pharm, Ctr Pharmacognosy & Phytotherapy, London WC1N 1AX, England

[2] Univ Freiburg, Sch Med, Dept Psychiat & Phychotherapy, Freiburg, Germany

[3] Univ Cordoba, Dept Cellular Biol Physiol & Immunol, Cordoba, Spain

[4] Univ Murcia, Dept Plant Biol, Fac Biol, Murcia, Spain

来源：

PLANTA MEDICA | 2004年 / 70卷 / 10期

关键词：

NF-kB; Bupleurum fruticosum; Apiaceae; phenylpropanoids; anti-inflammatory natural products (AINP) cytokine;

D O I：

10.1055/s-2004-832616

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two phenylpropanoids from Bupleurum fruticosum (Apiaceae/Umbelliferae) were shown to inhibit the transcriptional activity induced by PMA or TNFalpha of an NF-kappaB-controlled reporter gene. Western blot experiments indicated that the phenylpropanoids did not prevent IkappaBalpha degradation, suggesting that their molecular target is at a post-IKB degradation level. Both compounds prevented cytokine (IL-1, IL-6, TNF, IL-8) release and prostaglandin E-2 synthesis.

引用

页码：914 / 918

页数：5

共 22 条

[1] Regulation of NF-κB RelA phosphorylation and transcriptional activity by p21ras and protein kinase Cζ in primary endothelial cells
Anrather, J
Csizmadia, V
Soares, MP
Winkler, H
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (19) : 13594 - 13603
[2] BALLERO M, 1991, Fitoterapia, V62, P524
[3] Sesquiterpene lactone containing Mexican Indian medicinal plants and pure sesquiterpene lactones as potent inhibitors of transcription factor NF-kappa B
Bork, PM
Schmitz, ML
Kuhnt, M
Escher, C
Heinrich, M
[J]. FEBS LETTERS, 1997, 402 (01) : 85 - 90
[4] Natural products as targeted modulators of the nuclear factor-κB pathway
Bremner, P
Heinrich, M
[J]. JOURNAL OF PHARMACY AND PHARMACOLOGY, 2002, 54 (04) : 453 - 472
[5] Calixto JB, 2003, PLANTA MED, V69, P973, DOI [10.1055/s-2004-815483, 10.1055/s-2003-45141]
[6] Potent inhibition of lipopolysaccharide-inducible nitric oxide synthase expression by dibenzylbutyrolactone lignans through inhibition of I-κBα phosphorylation and of p65 nuclear translocation in macrophages
Cho, MK
Park, JW
Jang, YP
Kim, YC
Kim, SG
[J]. INTERNATIONAL IMMUNOPHARMACOLOGY, 2002, 2 (01) : 105 - 116
[7] Fiebich BL, 2004, PHYTOMEDICINE, V11, P135, DOI 10.1016/j.phymed.2004.03.003
[8] Missing pieces in the NF-κB puzzle
Ghosh, S
Karin, M
[J]. CELL, 2002, 109 : S81 - S96
[9] BIOLOGICALLY-ACTIVE TRITERPENE SAPONINS FROM BUPLEURUM-FRUTICOSUM
GUINEA, MC
PARELLADA, J
LACAILLEDUBOIS, MA
WAGNER, H
[J]. PLANTA MEDICA, 1994, 60 (02) : 163 - 167
[10] Gunther R T., 1968, GREEK HERBAL DIOSCOR, P297

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