High yielding microwave-assisted synthesis of 2-(arylmethyl)amino-4-arylamino-6-alkyl-1,3,5-triazines

被引：24

作者：

Chen, Huixiong ^{[1
]}

Dao, Pascal ^{[1
]}

Laporte, Alice ^{[1
]}

Garbay, Christiane ^{[1
]}

机构：

[1] Univ Paris 05, CNRS, Chim & Biochim Pharmacol & Toxicol Lab, UMR 8601,UFR Biomed, F-75270 Paris 06, France

来源：

TETRAHEDRON LETTERS | 2010年 / 51卷 / 24期

关键词：

2-(Arylmethyl)amino-4-arylamino-6-alkyl-1,3,5-triazines; Microwave synthesis; Cyclocondensation; SUBSTITUTED S-TRIAZINES; DERIVATIVES; INHIBITORS; CONVERSION; SERIES;

D O I：

10.1016/j.tetlet.2010.04.042

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学];

摘要：

An efficient and practical procedure was developed to prepare novel 2-(arylmethyl)amino-4-arylamino-6-alkyl-1,3,5-triazines, starting from dicyandiamide and the corresponding arylamines under microwave irradiation and its scope is demonstrated with a number of examples. The valuable feature of this procedure included the short reaction times, high yields, and easy operation. (C) 2010 Elsevier Ltd. All rights reserved.

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收藏

页码：3174 / 3176

页数：3

相关论文

共 20 条

[1]

Syntheses of 2,4,6-trisubstituted triazines as antimalarial agents [J].

Agarwal, A ;

Srivastava, K ;

Puri, SK ;

Chauhan, PMS .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2005, 15 (03) :531-533

[2]

Synthesis of pyrazino[1,2-a]benzimidazol-1(2H)ones via a microwave assisted Buchwald-Hartwig type reaction [J].

Alen, Jo ;

Robeyns, Koen ;

De Borggraeve, Wim M. ;

Van Meervelt, Luc ;

Compernolle, Frans .

TETRAHEDRON, 2008, 64 (35) :8128-8133

[3]

CONVERSION OF BIGUANIDES INTO SUBSTITUTED S-TRIAZINES ASSAYABLE BY GC OR MASS FRAGMENTOGRAPHY [J].

ALKALAY, D ;

VOLK, J ;

BARTLETT, MF .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1976, 65 (04) :525-529

[4]

Recent applications of 2,4,6-trichloro-1,3,5-triazine and its derivatives in organic synthesis [J].

Blotny, Grzegorz .

TETRAHEDRON, 2006, 62 (41) :9507-9522

[5]

Microwave-assisted solvent-free heterocyclic synthesis [J].

Bougrin, K ;

Loupy, A ;

Soufiaoui, M .

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY C-PHOTOCHEMISTRY REVIEWS, 2005, 6 (2-3) :139-167

[6]

Characterization of monoclonal antibodies raised against different structures belonging to the s-triazine group of herbicides [J].

Bruun, L ;

Koch, C ;

Jakobsen, MH ;

Pedersen, B ;

Christiansen, M ;

Aamand, J .

ANALYTICA CHIMICA ACTA, 2001, 436 (01) :87-101

[7]

AN EFFICIENT CONVERSION OF NITRILES TO AMIDINES [J].

GARIGIPATI, RS .

TETRAHEDRON LETTERS, 1990, 31 (14) :1969-1972

[8]

Novel inhibitors of Erm methyltransferases from NMR and parallel synthesis [J].

Hajduk, PJ ;

Dinges, J ;

Schkeryantz, JM ;

Janowick, D ;

Kaminski, M ;

Tufano, M ;

Augeri, DJ ;

Petros, A ;

Nienaber, V ;

Zhong, P ;

Hammond, R ;

Coen, M ;

Beutel, B ;

Katz, L ;

Fesik, SW .

JOURNAL OF MEDICINAL CHEMISTRY, 1999, 42 (19) :3852-3859

[9]

A new series of estrogen receptor modulators that display selectivity for estrogen receptor β [J].

Henke, BR ;

Consler, TG ;

Go, N ;

Hale, RL ;

Hohman, DR ;

Jones, SA ;

Lu, AT ;

Moore, LB ;

Moore, JT ;

Orband-Miller, LA ;

Robinett, RG ;

Shearin, J ;

Spearing, PK ;

Stewart, EL ;

Turnbull, PS ;

Weaver, SL ;

Williams, SP ;

Wisely, GB ;

Lambert, MH .

JOURNAL OF MEDICINAL CHEMISTRY, 2002, 45 (25) :5492-5505

[10]

NEW S-TRIAZINE DERIVATIVES AS DEPRESSANTS FOR RETICULOENDOTHELIAL HYPERFUNCTION INDUCED BY BACTERIAL ENDOTOXIN [J].

IRIKURA, T ;

ABE, Y ;

OKAMURA, K ;

HIGO, K ;

MAEDA, A ;

MORINAGA, F ;

SHIRAI, G ;

HATAE, S .

JOURNAL OF MEDICINAL CHEMISTRY, 1970, 13 (06) :1081-&