Primer unit specificity in rifamycin biosynthesis principally resides in the later stages of the biosynthetic pathways

被引:34
作者
Hunziker, D
Yu, TW
Hutchinson, CR
Floss, HG
Khosla, C [1 ]
机构
[1] Stanford Univ, Dept Chem Engn, Stanford, CA 94305 USA
[2] Stanford Univ, Dept Chem, Stanford, CA 94305 USA
[3] Stanford Univ, Dept Biochem, Stanford, CA 94305 USA
[4] Univ Wisconsin, Sch Pharm, Madison, WI 53706 USA
[5] Univ Wisconsin, Dept Bacteriol, Madison, WI 53706 USA
[6] Univ Washington, Dept Chem, Seattle, WA 98195 USA
关键词
D O I
10.1021/ja9736368
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
引用
收藏
页码:1092 / 1093
页数:2
相关论文
共 15 条
[1]   BIOSYNTHETIC ORIGINS OF THE OXYGEN-ATOMS IN THE ANSAMYCIN ANTIBIOTICS RIFAMYCIN-B, RIFAMYCIN-O, AND RIFAMYCIN-S [J].
ANDERSON, MG ;
MONYPENNY, D ;
RICKARDS, RW ;
ROTHSCHILD, JM .
JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1989, (05) :311-313
[2]   3-AMINO-5-HYDROXYBENZOIC ACID IN ANTIBIOTIC BIOSYNTHESIS .6. DIRECTED BIOSYNTHESIS STUDIES WITH ANSAMYCIN ANTIBIOTICS [J].
BECKER, AM ;
HERLT, AJ ;
HILTON, GL ;
KIBBY, JJ ;
RICKARDS, RW .
JOURNAL OF ANTIBIOTICS, 1983, 36 (10) :1323-1328
[3]   AN UNUSUALLY LARGE MULTIFUNCTIONAL POLYPEPTIDE IN THE ERYTHROMYCIN-PRODUCING POLYKETIDE SYNTHASE OF SACCHAROPOLYSPORA-ERYTHRAEA [J].
CORTES, J ;
HAYDOCK, SF ;
ROBERTS, GA ;
BEVITT, DJ ;
LEADLAY, PF .
NATURE, 1990, 348 (6297) :176-178
[4]   MODULAR ORGANIZATION OF GENES REQUIRED FOR COMPLEX POLYKETIDE BIOSYNTHESIS [J].
DONADIO, S ;
STAVER, MJ ;
MCALPINE, JB ;
SWANSON, SJ ;
KATZ, L .
SCIENCE, 1991, 252 (5006) :675-679
[5]   NOVEL AVERMECTINS PRODUCED BY MUTATIONAL BIOSYNTHESIS [J].
DUTTON, CJ ;
GIBSON, SP ;
GOUDIE, AC ;
HOLDOM, KS ;
PACEY, MS ;
RUDDOCK, JC ;
BULOCK, JD ;
RICHARDS, MK .
JOURNAL OF ANTIBIOTICS, 1991, 44 (03) :357-365
[6]   EARLY INTERMEDIATES IN BIOSYNTHESIS OF ANSAMYCINS .1. ISOLATION AND IDENTIFICATION OF PROTORIFAMYCIN-I [J].
GHISALBA, O ;
TRAXLER, P ;
NUESCH, J .
JOURNAL OF ANTIBIOTICS, 1978, 31 (11) :1124-1131
[7]   A GENETIC APPROACH TO THE BIOSYNTHESIS OF THE RIFAMYCIN-CHROMOPHORE IN NOCARDIA-MEDITERRANEI .3. ISOLATION AND IDENTIFICATION OF AN EARLY AROMATIC ANSAMYCIN-PRECURSOR CONTAINING THE 7-CARBON AMINO STARTER-UNIT AND 3 INITIAL ACETATE-PROPIONATE-UNITS OF THE ANSA CHAIN [J].
GHISALBA, O ;
FUHRER, H ;
RICHTER, WJ ;
MOSS, S .
JOURNAL OF ANTIBIOTICS, 1981, 34 (01) :58-63
[8]   A GENETIC APPROACH TO THE BIOSYNTHESIS OF THE RIFAMYCIN-CHROMOPHORE IN NOCARDIA-MEDITERRANEI .4. IDENTIFICATION OF 3-AMINO-5-HYDROXYBENZOIC ACID AS A DIRECT PRECURSOR OF THE 7-CARBON AMINO STARTER-UNIT [J].
GHISALBA, O ;
NUESCH, J .
JOURNAL OF ANTIBIOTICS, 1981, 34 (01) :64-71
[9]   SYNTHESIS OF UNLABELED AND CARBOXYL-LABELED 3-AMINO-5-HYDROXYBENZOIC ACID [J].
HERLT, AJ ;
KIBBY, JJ ;
RICKARDS, RW .
AUSTRALIAN JOURNAL OF CHEMISTRY, 1981, 34 (06) :1319-1324
[10]   Precursor-directed biosynthesis of erythromycin analogs by an engineered polyketide synthase [J].
Jacobsen, JR ;
Hutchinson, CR ;
Cane, DE ;
Khosla, C .
SCIENCE, 1997, 277 (5324) :367-369