Polycomb group protein Ezh1 represses Nodal and maintains the left-right axis

被引：6

作者：

Arai, Daisuke ^{[1
]}

Katsura, Hiroaki ^{[1
]}

Shindo, Norihisa ^{[1
]}

Matsumoto, Mayuko ^{[1
]}

Higashinakagawa, Toru ^{[1
]}

机构：

[1] Waseda Univ, Dept Biol, Shinjuku Ku, Tokyo 1628480, Japan

来源：

DEVELOPMENTAL BIOLOGY | 2010年 / 341卷 / 02期

关键词：

Ezh1; Left-right axis; Medaka; Nodal; Polycomb; LEFT-RIGHT ASYMMETRY; HEDGEHOG SIGNALING PATHWAY; KUPFFERS VESICLE; LATERAL PLATE; MOUSE EMBRYO; HISTONE H3; EXPRESSION; GENE; MEDAKA; FLOW;

D O I：

10.1016/j.ydbio.2010.03.002

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The left-right (LR) axis is essential for the proper function of internal organs. In mammals and fish, left-sided Nodal expression governs LR patterning. Here, we show that the Polycomb group protein Ezh1, which is highly conserved from fish to human, participates in LR patterning. Knockdown of olezh1, a medaka homologue of Ezh1, led to LR reversal of internal organs. It was shown that OLEZH1 acts in silencing the expression of Spaw (a medaka homolog of Nodal) via a previously unknown pathway. Furthermore, coimmunoprecipitation showed physical interaction of Ezh1 with FoxH1, a Nodal regulator. This represents a novel mechanism for LR patterning and implies that Ezh1 has developmental importance. (C) 2010 Elsevier Inc. All rights reserved.

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收藏

页码：459 / 463

页数：5

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