Inhibition of phospholipase Cγ1 and cancer cell proliferation by triterpene esters from Uncaria rhynchophylla

被引：69

作者：

Lee, JS

Kim, J ^{[1
]}

Kim, BY

Lee, HS

Ahn, JS

Chang, YS

机构：

[1] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea

[2] Korea Res Inst Biosci & Biotechnol, Taejon 305600, South Korea

[3] China Med Coll, Taichung, Taiwan

来源：

JOURNAL OF NATURAL PRODUCTS | 2000年 / 63卷 / 06期

关键词：

D O I：

10.1021/np990478k

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Investigation of the hooks of Uncaria rhynchophylla resulted in isolation of six phospholipase C gamma 1 (PLC gamma 1) inhibitors (1-6). The structures of these compounds were elucidated as pentacyclic triterpene esters by spectroscopic and chemical analysis. Three of them, namely uncarinic acids C (1), D (2), and E (3), are newly reported as natural products. All the compounds showed dose-dependent inhibitory activities against PLC gamma 1 in vitro with IC50 values of 9.5-44.8 mu M and inhibited the proliferation of human cancer cells with IC50 values of 0.5-6.5 mu g/mL.

引用

页码：753 / 756

页数：4

共 26 条

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