Absence of surface expression of feline infectious peritonitis virus (FIPV) antigens on infected cells isolated from cats with FIP

被引：20

作者：

Cornelissen, E. ^{[1
]}

Dewerchin, H. L. ^{[1
]}

Van Hamme, E. ^{[1
]}

Nauwynck, H. J. ^{[1
]}

机构：

[1] Univ Ghent, Fac Vet Med, Lab Virol, B-9820 Merelbeke, Belgium

来源：

VETERINARY MICROBIOLOGY | 2007年 / 121卷 / 1-2期

关键词：

feline infectious peritonitis; viral antigen-expression; MHC I; immune-evasion;

D O I：

10.1016/j.vetmic.2006.11.026

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Feline infectious peritonitis virus (FIPV) positive cells are present in pyogranulomas and exudates from cats with FIR These cells belong mainly to the monocyte/macrophage lineage. How these cells survive in immune cats is not known. In this study, FIPV positive cells were isolated from pyogranulomas and exudates of 12 naturally FIPV-infected cats and the presence of two immunologic targets, viral antigens and MHC I, on their surface was determined. The majority of the infected cells were confirmed to be cells from the monocyte/macrophage lineage. No surface expression of viral antigens was detected on FIPV positive cells. MHC I molecules were present on all the FIPV positive cells. After cultivation of the isolated infected cells, 52 +/- 10% of the infected cells re-expressed viral antigens on the plasma membrane. In conclusion, it can be stated that in FIP cats, FIPV replicates in cells of the monocyte/macrophage lineage without carrying viral antigens in their plasma membrane, which could allow them to escape from antibody-dependent cell lysis. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：131 / 137

页数：7

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