Neoglycopeptide dendrimer libraries as a source of lectin binding ligands

被引：69

作者：

Kolomiets, Elena

Johansson, Emma M. V.

Renaudet, Olivier

Darbre, Tamis

Reymond, Jean-Louis

机构：

[1] Univ Bern, Dept Chem & Biochem, CH-3012 Bern, Switzerland

[2] Univ Grenoble 1, DCM, UMR 5250, CNRS, F-38041 Grenoble 9, France

[3] Univ Grenoble 1, ICMG FR 2607, F-38041 Grenoble 9, France

来源：

ORGANIC LETTERS | 2007年 / 9卷 / 08期

关键词：

D O I：

10.1021/ol070119d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A 15 625-membered peptide dendrimer combinatorial library was acylated with an alpha-C-fucosyl residue at its four N-termini and screened for binding to fucose-specific lectins. Dendrimer FD2 (Fuc-alpha-CH2CO-Lys-Pro-Leu)(4)(Lys-Phe-Lys-Ile)(2)Lys-His-Ile-NH2 was identified as a potent ligand against Ulex europaeus lectin UEA-I (IC50 = 11 mu M) and Pseudomonas aeruginosa lectin PA-IIL (IC50 = 0.14 mu M).

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页码：1465 / 1468

页数：4

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