Brainstem prolactin mRNA is enhanced in mice with suppressed neuronal nitric oxide synthase activity

被引：8

作者：

Chen, LC ^{[1
]}

Taishi, P ^{[1
]}

Duricka, D ^{[1
]}

Krueger, JM ^{[1
]}

机构：

[1] Washington State Univ, Dept Vet & Comparat Anat Pharmacol & Physiol, Pullman, WA 99164 USA

来源：

MOLECULAR BRAIN RESEARCH | 2004年 / 129卷 / 1-2期

关键词：

sleep; brainstem; cytokine; nitric oxide; VIP; prolactin;

D O I：

10.1016/j.molbrainres.2004.06.018

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Prolactin (PRL) and vasoactive intestinal polypeptide (VIP) mRNA levels were elevated in the brainstem of neuronal nitric oxide synthase (nNOS) gene knockout (KO) mice compared to the levels in nNOS control mice. In addition, PRL mRNA levels increased in the hypothalamus and the brainstem of nNOS control mice after administration of 7-nitro-indazole (7-NI), a relatively selective nNOS inhibitor. The results suggest that NO inhibits PRL. No differences in the genes measured were observed in inducible NOS KO mice. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：179 / 184

页数：6

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