Evolutionary and functional perspectives of the major histocompatibility complex class I antigen-processing machinery

被引：31

作者：

Paulsson, KM ^{[1
]}

机构：

[1] UCL, Rayne Inst, Ctr Mol Med, Dept Med, London WC1E 6JJ, England

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2004年 / 61卷 / 19-20期

关键词：

endoplasmic reticulum (ER); MHC class I; tapasin; TAP; ERp57; ERAP1/ERAAP; proteasome; antigen-processing machinery (APM);

D O I：

10.1007/s00018-004-4113-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Major histocompatibility complex (MHC) class I molecules present antigenic peptides to CD8(+) T cells, providing the basis for immune recognition of pathogen-infected cells. Peptides generated mainly by proteasomes in the cytosol are transported into the lumen of the endoplasmic reticulum by transporters associated with antigen processing ( TAP). The maturation of MHC class I molecules is controlled by a number of accessory proteins and chaperones that are to a varying degree dedicated to the assembly of MHC class I. Several newly characterised proteins have been demonstrated to play important roles in this process. This review focuses on the functional relationship and evolutionary history of the antigen-processing machinery (APM) components and MHC class I itself. These are of great interest for further elucidating the origin of the immune system and understanding the mechanisms of antigen presentation and immunology in general.

引用

页码：2446 / 2460

页数：15

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