Transcriptional networks: reverse-engineering gene regulation on a global scale

被引：47

作者：

Chua, G ^{[1
]}

Robinson, MD ^{[1
]}

Morris, Q ^{[1
]}

Hughes, TR ^{[1
]}

机构：

[1] Univ Toronto, Banting & Best Dept Med Res, Toronto, ON M5G 1L6, Canada

来源：

CURRENT OPINION IN MICROBIOLOGY | 2004年 / 7卷 / 06期

基金：

加拿大健康研究院; 加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1016/j.mib.2004.10.009

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A major objective in post-genome research is to fully understand the transcriptional control of each gene and the targets of each transcription factor. In yeast, large-scale experimental and computational approaches have been applied to identify co-regulated genes, cis regulatory elements, and transcription factor DNA binding sites in vivo. Methods for modeling and predicting system behavior, and for reconciling discrepancies among data types, are being explored. The results indicate that a complete and comprehensive yeast transcriptional network will ultimately be achieved.

引用

页码：638 / 646

页数：9

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