The potential autocrine/paracrine roles of ghrelin and its receptor in hormone-dependent cancer

被引：105

作者：

Jeffery, PL ^{[1
]}

Herington, AC ^{[1
]}

Chopin, LK ^{[1
]}

机构：

[1] Queensland Univ Technol, Brisbane, Qld 4000, Australia

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2003年 / 14卷 / 02期

关键词：

ghrelin; growth hormone secretagogues (GHSs); growth hormone secretagogue receptor (GHS-R); growth hormone (GH); insulin-like growth factors (IGFs);

D O I：

10.1016/S1359-6101(02)00089-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ghrelin is a recently identified 28 amino acid peptide capable of stimulating pituitary growth hormone release in humans. The actions of ghrelin are mediated via the naturally occurring ghrelin receptor, also known as the growth hormone secretagogue receptor (GHS-R). Ghrelin and its receptors are now being recognized as components of the growth hormone axis and are therefore potentially involved in tissue growth and development. As is the case for other members of this axis, evidence is rapidly emerging to indicate that ghrelin/GHS-R may play an important autocrine/paracrine role in some cancers. This review highlights the evidence for the expression, regulation and potential functional role of ghrelin and its receptor in hormone-dependent cancers, such as prostate and breast cancer. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：113 / 122

页数：10

共 110 条

[1] Preliminary evidence that Ghrelin, the natural GH secretagogue (GHS)-receptor ligand, strongly stimulates GH secretion in humans [J].

Arvat, E ;

Di Vito, L ;

Broglio, F ;

Papotti, M ;

Muccioli, G ;

Dieguez, C ;

Casanueva, FF ;

Deghenghi, R ;

Camanni, F ;

Ghigo, E .

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 2000, 23 (08) :493-495

[2] Effects of GHRP-2 and hexarelin, two synthetic GH-releasing peptides, on GH, prolactin, ACTH and cortisol levels in man. Comparison with the effects of GHRH, TRH and hCRH [J].

Arvat, E ;

diVito, L ;

Maccagno, B ;

Broglio, F ;

Boghen, MF ;

Deghenghi, R ;

Camanni, F ;

Ghigo, E .

PEPTIDES, 1997, 18 (06) :885-891

[3] IMMUNOHISTOLOGICAL LOCALIZATION OF GROWTH HORMONE-RELEASING HORMONE IN HUMAN-TUMORS [J].

ASA, SL ;

KOVACS, K ;

THORNER, MO ;

LEONG, DA ;

RIVIER, J ;

VALE, W .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1985, 60 (03) :423-427

[4] Extent and direction of ghrelin transport across the blood-brain barrier is determined by its unique primary structure [J].

Banks, WA ;

Tschöp, M ;

Robinson, SM ;

Heiman, ML .

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2002, 302 (02) :822-827

[5]

Barlier A, 1999, J NEUROENDOCRINOL, V11, P491

[6] Antiproliferative and pro-apoptotic activities of insulin-like growth factor-binding protein-3 [J].

Baxter, RC ;

Butt, AJ ;

Schedlich, LJ ;

Martin, JL .

GROWTH HORMONE & IGF RESEARCH, 2000, 10 :S10-S11

[7] Structure-function studies on the new growth hormone-releasing peptide, ghrelin: Minimal sequence of ghrelin necessary for activation of growth hormone secretagogue receptor 1a [J].

Bednarek, MA ;

Feighner, SD ;

Pong, SS ;

McKee, KK ;

Hreniuk, DL ;

Silva, MV ;

Warren, VA ;

Howard, AD ;

Van der Ploeg, LHY ;

Heck, JV .

JOURNAL OF MEDICINAL CHEMISTRY, 2000, 43 (23) :4370-4376

[8] THE PITUITARY-SPECIFIC TRANSCRIPTION FACTOR-GHF-1 IS A HOMEOBOX-CONTAINING PROTEIN [J].

BODNER, M ;

CASTRILLO, JL ;

THEILL, LE ;

DEERINCK, T ;

ELLISMAN, M ;

KARIN, M .

CELL, 1988, 55 (03) :505-518

[9] ON THE INVITRO AND INVIVO ACTIVITY OF A NEW SYNTHETIC HEXAPEPTIDE THAT ACTS ON THE PITUITARY TO SPECIFICALLY RELEASE GROWTH-HORMONE [J].

BOWERS, CY ;

MOMANY, FA ;

REYNOLDS, GA ;

HONG, A .

ENDOCRINOLOGY, 1984, 114 (05) :1537-1545

[10] STRUCTURE-ACTIVITY-RELATIONSHIPS OF A SYNTHETIC PENTAPEPTIDE THAT SPECIFICALLY RELEASES GROWTH-HORMONE INVITRO [J].

BOWERS, CY ;

MOMANY, F ;

REYNOLDS, GA ;

CHANG, D ;

HONG, A ;

CHANG, K .

ENDOCRINOLOGY, 1980, 106 (03) :663-667

← 1 2 3 4 5 6 7 8 9 10 →