Structure, conformation, and dynamics of bioactive oligosaccharides:: Theoretical approaches and experimental validations

被引:224
作者
Imberty, A [1 ]
Pérez, S [1 ]
机构
[1] Univ Grenoble 1, CNRS, CERMAV, F-38041 Grenoble 9, France
关键词
D O I
10.1021/cr990343j
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A review is given on the significant contributions in the elucidation and understanding of the conformations and dynamics of oligosaccharides, restricting the examples to some carbohydrate molecules that are considered to possess a significant biological function. Focus is on molecules belonging to the class of histo-blood-group antigens and to the glycosaminoglycan family for which a range of conformational characterizations has been reported.
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收藏
页码:4567 / 4588
页数:22
相关论文
共 264 条
[1]   Conformational differences between Fuc(α1-3)GlcNAc and its thioglycoside analogue [J].
Aguilera, B ;
Jiménez-Barbero, J ;
Fernández-Mayoralas, A .
CARBOHYDRATE RESEARCH, 1998, 308 (1-2) :19-27
[2]   Synthesis of tethered trisaccharides to probe inter-saccharide flexibility in carbohydrate-protein interactions [J].
Alibés, R ;
Bundle, DR .
JOURNAL OF ORGANIC CHEMISTRY, 1998, 63 (18) :6288-6301
[3]  
Allen F.H., 1993, CHEM AUTOMAT NEWS, V8, P31
[4]   CONFORMATIONAL-ANALYSIS .130. MM2 - HYDROCARBON FORCE-FIELD UTILIZING V1 AND V2 TORSIONAL TERMS [J].
ALLINGER, NL .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1977, 99 (25) :8127-8134
[5]   MOLECULAR MECHANICS - THE MM3 FORCE-FIELD FOR HYDROCARBONS .1. [J].
ALLINGER, NL ;
YUH, YH ;
LII, JH .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1989, 111 (23) :8551-8566
[6]   A MOLECULAR MECHANICS FORCE-FIELD (MM3) FOR ALCOHOLS AND ETHERS [J].
ALLINGER, NL ;
RAHMAN, M ;
LII, JH .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1990, 112 (23) :8293-8307
[7]  
ALLINGER NL, 1990, J AM CHEM SOC, V112, P6120
[8]   Molecular dynamics simulations of the two disaccharides of hyaluronan in aqueous solution [J].
Almond, A ;
Sheehan, JK ;
Brass, A .
GLYCOBIOLOGY, 1997, 7 (05) :597-604
[9]   The mean hydration of carbohydrates as studied by normalized two-dimensional radial pair distributions [J].
Andersson, C ;
Engelsen, SB .
JOURNAL OF MOLECULAR GRAPHICS & MODELLING, 1999, 17 (02) :101-+
[10]   Bovine heart galectin-1 selects a unique (Syn) conformation of C-lactose, a flexible lactose analogue [J].
Asensio, JL ;
Espinosa, JF ;
Dietrich, H ;
Cañada, FJ ;
Schmidt, RR ;
Martín-Lomas, M ;
André, S ;
Gabius, HJ ;
Jiménez-Barbero, J .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (39) :8995-9000