An extremely active catalyst for the Negishi cross-coupling reaction

被引：378

作者：

Milne, JE ^{[1
]}

Buchwald, SL ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2004年 / 126卷 / 40期

关键词：

D O I：

10.1021/ja0474493

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new catalyst system for the Pd-catalyzed cross-coupling of organozinc reagents with aryl halides (Negishi coupling) has been developed. This system permits efficient preparation of hindered biaryls (tri-and tetra-ortho-substituted), functions effectively at low levels of catalyst, and tolerates a wide range of functional groups and heterocyclic substrates. A systematic study of ligand structure was performed and was correlated with catalyst activity.

引用

页码：13028 / 13032

页数：5

共 28 条

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