Occupational exposure to terbufos and the incidence of cancer in the Agricultural Health Study

被引:75
作者
Bonner, Matthew R. [1 ]
Williams, Brent A. [1 ]
Rusiecki, Jennifer A. [2 ]
Blair, Aaron [3 ]
Freeman, Laura E. Beane [3 ]
Hoppin, Jane A. [4 ]
Dosemeci, Mustafa [3 ]
Lubin, Jay [5 ]
Sandler, Dale P. [4 ]
Alavanja, Michael C. R. [3 ]
机构
[1] SUNY Buffalo, Dept Social & Prevent Med, Sch Publ Hlth & Hlth Profess, Buffalo, NY 14260 USA
[2] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA
[3] NCI, Occupat & Environm Epidemiol Branch, Div Canc Epidemiol & Genet, NIH,Dept Hlth & Human Serv, Bethesda, MD 20892 USA
[4] Natl Inst Environm Hlth Sci, Epidemiol Branch, NIH, Dept Hlth & Human Serv, Res Triangle Pk, NC USA
[5] NCI, Biostat Branch, Div Canc Epidemiol & Genet, NIH,Dept Hlth & Human Serv, Bethesda, MD 20892 USA
基金
美国国家卫生研究院;
关键词
Cancer incidence; Terbufos; Organophosphate insecticides; PESTICIDE USE; PROSTATE-CANCER; RISK-FACTORS; APPLICATORS; IOWA; MEN;
D O I
10.1007/s10552-010-9514-9
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Terbufos is the fourth most commonly used organophosphate insecticide (OP) in the United States. Terbufos has not been demonstrated to be carcinogenic in rodents, although non-arsenical insecticides, including OPs, have been associated with excess cancer in epidemiologic studies. We investigated associations between use of terbufos and the incidence of cancer. The Agricultural Health Study is a prospective cohort study of 57,310 licensed pesticide applicators from Iowa and North Carolina. Detailed information about 50 pesticides, including terbufos, and potential confounders was obtained from self-administered questionnaires. Terbufos intensity-weighted lifetime exposure-days were defined as (lifetime exposure-days) x (exposure intensity score). Cases include all first primary cancers diagnosed between enrollment and December 31, 2005. Hazard ratios (HR) and 95% CI were calculated with Cox proportional hazards models, adjusting for potential confounders. Overall cancer risk was slightly increased among terbufos users [HR 1.21 (1.06-1.37)]. Suggestive associations were observed between terbufos use and cancers of the prostate (HRhighest tertile = 1.21; 95% CI = 0.99-1.47) and lung (HRmiddle tertile = 1.45; 95% CI = 0.95-2.22) and leukemia (HRmiddle tertile = 2.38; 95% CI = 1.35-4.21) and non-Hodgkin's lymphoma (HRmiddle tertile = 1.94; 95% CI = 1.16-3.22), although the exposure-response gradients were non-monotonic and p for trends were not significant. We found suggestive associations between occupational terbufos use and several cancer sites. However, cautious interpretation of these results is warranted by the lack of existing experimental and epidemiologic evidence to support carcinogenic effects of terbufos.
引用
收藏
页码:871 / 877
页数:7
相关论文
共 30 条
[21]   Accuracy of self-reported pesticide use duration information from licensed pesticide applicators in the Agricultural Health Study [J].
Hoppin, JA ;
Yucel, F ;
Dosemeci, M ;
Sandler, DP .
JOURNAL OF EXPOSURE ANALYSIS AND ENVIRONMENTAL EPIDEMIOLOGY, 2002, 12 (05) :313-318
[22]  
Kiely T., 2004, Pesticides Industry Sales and Usage - 2000 and 2001 Market Estimates
[23]   Cancer incidence among pesticide applicators exposed to chlorpyrifos in the agricultural health study [J].
Lee, WJ ;
Blair, A ;
Hoppin, JA ;
Lubin, JH ;
Rusiecki, JA ;
Sandler, DP ;
Dosemeci, M ;
Alavanja, MCR .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2004, 96 (23) :1781-1789
[24]   Pesticide use and colorectal cancer risk in the Agricultural Health Study [J].
Lee, Won Jin ;
Sandler, Dale P. ;
Blair, Aaron ;
Samanic, Claudine ;
Cross, Amanda J. ;
Alavanja, Michael C. R. .
INTERNATIONAL JOURNAL OF CANCER, 2007, 121 (02) :339-346
[25]   Fonofos exposure and cancer incidence in the Agricultural Health Study [J].
Mahajan, Raieev ;
Blair, Aaron ;
Lynch, Charles F. ;
Schroeder, Paul ;
Hoppin, Jane A. ;
Sandler, Dale P. ;
Alavanja, Michael C. R. .
ENVIRONMENTAL HEALTH PERSPECTIVES, 2006, 114 (12) :1838-1842
[26]  
Maroni M, 2000, TOXICOLOGY, V143, P1
[27]  
MCCALL DL, 1995, REVISED HUMAN HLTH A
[28]   Pesticides and prostate cancer: a review of epiderniologic studies with specific agricultural exposure information [J].
Mink, Pamela J. ;
Adami, Hans-Olov ;
Trichopoulos, Dimitrios ;
Britton, Nicole L. ;
Mandel, Jack S. .
EUROPEAN JOURNAL OF CANCER PREVENTION, 2008, 17 (02) :97-110
[29]  
Percy C., 1990, International Classification of Diseases for Oncology, V2nd
[30]  
*USEPA, 2001, INT RER EL DEC TERB