Asymmetric aminohydroxylation of substituted styrenes using t-butyl carbamate

被引：23

作者：

O'Brien, P ^{[1
]}

Osborne, SA

Parker, DD

机构：

[1] Univ York, Dept Chem, York YO1 5DD, N Yorkshire, England

[2] Parke Davis Neurosci Res Ctr, Cambridge CB2 2QB, England

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 23期

关键词：

D O I：

10.1016/S0040-4039(98)00665-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A variety of substituted styrenes have been aminohydroxylated using t-butyl carbamate to give either enantiomer of highly enantiomerically enriched N-Boc protected amino alcohols in good yields. Better levels of regioselectivity were observed with (DHQ)(2)PHAL than with (DHQD)(2)PHAL even though the enantioselectivities observed were comparable. One of the amino alcohol products was converted into a novel chiral diamine. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：4099 / 4102

页数：4

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