First catalytic, enantioselective aldol-Tishchenko reactions with ketone aldols as enol equivalents

被引：36

作者：

Schneider, C ^{[1
]}

Hansch, M ^{[1
]}

机构：

[1] Univ Gottingen, Inst Organ Chem, D-37077 Gottingen, Germany

来源：

SYNLETT | 2003年 / 06期

关键词：

aldol reaction; asymmetric catalysis; ketone aldols; Tishchenko reduction; zirconium;

D O I：

10.1055/s-2003-38741

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chiral zirconiumTADDOLates were found to catalyze the aldol-Tishchenko reaction of diacetone alcohol (1a) and two other ketone aldol adducts 1b and 1c with a range of aldehydes giving rise to differentiated 1,3-anti-diol monoesters in good yields, complete diastereocontrol and moderate enantioselectivities.

引用

页码：837 / 840

页数：4

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