Fibrogenesis V.: TGF-β signaling pathways

被引：137

作者：

Wells, RG

机构：

[1] Yale Univ, Sch Med, Dept Internal Med, New Haven, CT 06520 USA

[2] Yale Univ, Sch Med, Dept Pathol, New Haven, CT 06520 USA

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY | 2000年 / 279卷 / 05期

关键词：

fibrosis; extracellular matrix; transforming growth factor-beta receptors; Smads;

D O I：

10.1152/ajpgi.2000.279.5.G845

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Transforming growth factor (TGF)-beta is a multifunctional peptide growth factor with a wide range of potential effects on growth, differentiation, extracellular matrix deposition, and the immune response. General TGF-beta signaling pathways have been described in detail over the last several years, but factors that determine the nature of the TGF-beta response are poorly understood. In particular, signaling pathways that specifically mediate the matrix effects of TGF-beta have received little attention, although they will be important therapeutic targets in the treatment of pathological fibrosis. This themes article focuses on TGF-beta signaling and highlights potential points for generating matrix-specific responses.

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收藏

页码：G845 / G850

页数：6

相关论文

共 37 条

[11] Smad2 and Smad3 positively and negatively regulate TGFβ-dependent transcription through the forkhead DNA-Binding protein FAST2 [J].

Labbe, E ;

Silvestri, C ;

Hoodless, PA ;

Wrana, JL ;

Attisano, L .

MOLECULAR CELL, 1998, 2 (01) :109-120

[12] Two divergent signaling pathways for TGF-β separated by a mutation of its type II receptor gene [J].

Lu, SL ;

Kawabata, M ;

Imamura, T ;

Miyazono, K ;

Yuasa, Y .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1999, 259 (02) :385-390

[13] Positive and negative regulation of type II TGF beta receptor signal transduction by autophosphorylation on multiple serine residues [J].

Luo, KX ;

Lodish, HF .

EMBO JOURNAL, 1997, 16 (08) :1970-1981

[14] The integrin αvβ6 binds and activates latent TGFβ1:: A mechanism for regulating pulmonary inflammation and fibrosis [J].

Munger, JS ;

Huang, XZ ;

Kawakatsu, H ;

Griffiths, MJD ;

Dalton, SL ;

Wu, JF ;

Pittet, JF ;

Kaminski, N ;

Garat, C ;

Matthay, MA ;

Rifkin, DB ;

Sheppard, D .

CELL, 1999, 96 (03) :319-328

[15] Identification of Smad7, a TGF beta-inducible antagonist of TGF-beta signalling [J].

Nakao, A ;

Afrakhte, M ;

Moren, A ;

Nakayama, T ;

Christian, JL ;

Heuchel, R ;

Itoh, S ;

Kawabata, N ;

Heldin, NE ;

Heldin, CH ;

tenDijke, P .

NATURE, 1997, 389 (6651) :631-635

[16] Transient gene transfer and expression of Smad7 prevents bleomycin-induced lung fibrosis in mice [J].

Nakao, A ;

Fujii, M ;

Matsumura, R ;

Kumano, K ;

Saito, Y ;

Miyazono, K ;

Iwamoto, T .

JOURNAL OF CLINICAL INVESTIGATION, 1999, 104 (01) :5-11

[17] A histone deacetylase inhibitor, trichostatin A, suppresses myofibroblastic differentiation of rat hepatic stellate cells in primary culture [J].

Niki, T ;

Rombouts, K ;

De Bleser, P ;

De Smet, K ;

Rogiers, V ;

Schuppan, D ;

Yoshida, M ;

Gabbiani, G ;

Geerts, A .

HEPATOLOGY, 1999, 29 (03) :858-867

[18] Specificity, diversity, and regulation in TGF-β superfamily signaling [J].

Piek, E ;

Heldin, CH ;

Ten Dijke, P .

FASEB JOURNAL, 1999, 13 (15) :2105-2124

[19] Role of transforming growth factor β type II receptor in hepatic fibrosis:: Studies of human chronic hepatitis C and experimental fibrosis in rats [J].

Roulot, D ;

Sevcsik, AM ;

Coste, T ;

Strosberg, AD ;

Marullo, S .

HEPATOLOGY, 1999, 29 (06) :1730-1738

[20] Identification of important regions in the cytoplasmic juxtamembrane domain of type I receptor that separate signaling pathways of transforming growth factor-beta [J].

Saitoh, M ;

Nishitoh, H ;

Amagasa, T ;

Miyazono, K ;

Takagi, M ;

Ichijo, H .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (05) :2769-2775

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