Nicotinamide adenine dinucleotide, a metabolic regulator of transcription, longevity and disease

被引：401

作者：

Lin, SJ ^{[1
]}

Guarente, L ^{[1
]}

机构：

[1] MIT, Dept Biol, Cambridge, MA 02139 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2003年 / 15卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0955-0674(03)00006-1

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Nicotinamide adenine dinucleotide (NAD) is a ubiquitous biological molecule that participates in many metabolic reactions. Recent studies show that NAD also plays important roles in transcriptional regulation, longevity, calorie-restriction-mediated life-span extension and age-associated diseases. It has been shown that NAD affects longevity and transcriptional silencing through the regulation of the Sir2p family, which are NAD-dependent deacetylases. Many human diseases are associated with changes in NAD level and/or the NAD : NADH ratio, raising the possibility that the Sir2p family might play a role in these diseases.

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收藏

页码：241 / 246

页数：6

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