Differential neuropsychiatric symptom responses to tacrine in Alzheimer's disease: Relationship to dementia severity

被引：55

作者：

Kaufer, D

Cummings, JL

Christine, D

机构：

[1] Univ Pittsburgh, Med Ctr, Sch Med, Dept Psychiat, Pittsburgh, PA 15213 USA

[2] Univ Pittsburgh, Sch Med, Dept Neurol, Pittsburgh, PA 15261 USA

[3] Univ Calif Los Angeles, Sch Med, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90024 USA

[4] W Los Angeles Vet Affairs Med Ctr, Behav Neurosci Sect, Psychiat Serv, Los Angeles, CA 90073 USA

[5] W Los Angeles Vet Affairs Med Ctr, Nursing Serv, Los Angeles, CA 90073 USA

[6] Univ Calif Los Angeles, Sch Med, Dept Neurol, Los Angeles, CA 90024 USA

来源：

JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES | 1998年 / 10卷 / 01期

关键词：

D O I：

10.1176/jnp.10.1.55

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Neuropsychiatric symptom responses to tacrine were investigated in an open-label study of Alzheimer's outpatients. Forty subjects were stratified into three groups (Mild, Moderate, and Severe) based on Mini-Mental State Examination scores. A significant reduction in total Neuropsychiatric Inventory score across all subjects was principally attributable to changes in the Moderate group. Apathy and disinhibition symptoms were significantly reduced overall. Whereas other symptoms showed differential responses in Mild and Severe subjects, all symptoms improved in Moderate subjects. These findings suggest that disease severity may significantly influence neuropsychiatric symptom responses to tacrine. Putative mechanisms underlying the observed pattern of responses are explored.

引用

页码：55 / 63

页数：9

共 51 条

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