Regulating the construction and demolition of the synaptonemal complex

被引：166

作者：

Cahoon, Cori K. ^{[1
]}

Hawley, R. Scott ^{[1
,2
]}

机构：

[1] Stowers Inst Med Res, Kansas City, MO USA

[2] Univ Kansas, Med Ctr, Dept Mol & Integrat Physiol, Kansas City, KS 66103 USA

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2016年 / 23卷 / 05期

关键词：

CHROMOSOMAL PASSENGER COMPLEX; MEIOTIC CROSSING-OVER; DOUBLE-STRAND BREAKS; POLO-LIKE KINASE; AURORA-B KINASE; C-ELEGANS; CROSSOVER INTERFERENCE; SYNAPSIS INITIATION; HOMOLOG ALIGNMENT; CHIASMA FORMATION;

D O I：

10.1038/nsmb.3208

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The synaptonemal complex (SC) is a meiosis-specific scaffold that links homologous chromosomes from end to end during meiotic prophase and is required for the formation of meiotic crossovers. Assembly of SC components is regulated by a combination of associated nonstructural proteins and post-translational modifications, such as SUMOylation, which together coordinate the timing between homologous chromosome pairing, double-strand-break formation and recombination. In addition, transcriptional and translational control mechanisms ensure the timely disassembly of the SC after crossover resolution and before chromosome segregation at anaphase I.

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收藏

页码：369 / 377

页数：9

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