Regulating the construction and demolition of the synaptonemal complex

被引：166

作者：

Cahoon, Cori K. ^{[1
]}

Hawley, R. Scott ^{[1
,2
]}

机构：

[1] Stowers Inst Med Res, Kansas City, MO USA

[2] Univ Kansas, Med Ctr, Dept Mol & Integrat Physiol, Kansas City, KS 66103 USA

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2016年 / 23卷 / 05期

关键词：

CHROMOSOMAL PASSENGER COMPLEX; MEIOTIC CROSSING-OVER; DOUBLE-STRAND BREAKS; POLO-LIKE KINASE; AURORA-B KINASE; C-ELEGANS; CROSSOVER INTERFERENCE; SYNAPSIS INITIATION; HOMOLOG ALIGNMENT; CHIASMA FORMATION;

D O I：

10.1038/nsmb.3208

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The synaptonemal complex (SC) is a meiosis-specific scaffold that links homologous chromosomes from end to end during meiotic prophase and is required for the formation of meiotic crossovers. Assembly of SC components is regulated by a combination of associated nonstructural proteins and post-translational modifications, such as SUMOylation, which together coordinate the timing between homologous chromosome pairing, double-strand-break formation and recombination. In addition, transcriptional and translational control mechanisms ensure the timely disassembly of the SC after crossover resolution and before chromosome segregation at anaphase I.

引用

收藏

页码：369 / 377

页数：9

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