New steroidal alkaloids from Sarcococca saligna

被引：19

作者：

Rahman, A ^{[1
]}

Choudhary, MI ^{[1
]}

Khan, MR ^{[1
]}

Anjum, S ^{[1
]}

Farooq, A ^{[1
]}

Iqbal, MZ ^{[1
]}

机构：

[1] Univ Karachi, Natl Nematol Res Ctr, Int Ctr Chem Sci, Karachi 75270, Pakistan

来源：

JOURNAL OF NATURAL PRODUCTS | 2000年 / 63卷 / 10期

关键词：

D O I：

10.1021/np990108w

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Five new pregnane-type steroidal alkaloids (1-5) have been isolated from Sarcococca saligna. A combination of UV, IR, MS, and 1D and 2D NMR spectroscopic studies established their structures as salignarine A [(20S);2 beta -hydroxy-4 beta -acetoxy-5 alpha ,6 alpha -epoxy-20-(dimethylamino)-3 beta-(tigloylamino)pregnane] (1), salignarine B [(20S)-2 beta -hydroxy-20-(dimethylamino)-3 beta-(tigloylamino)-pregn-5-ene] (2), salignarine C [(20S)-2 beta -hydroxy-20-(dimethylamino)-3 beta-(senecioylamino)-pregn-5-ene] (3), salignarine D [(20S)-20- dimethylamino)-3 beta-(senecioylamino)-5 alpha -pregn-16-ene] (4), and salignarine E [(20S)-20-(dimethlyamino-3 beta-(tigloylamino)-pregn-4-ene] (5), respectively.

引用

页码：1364 / 1368

页数：5

共 11 条

[1] Antibacterial steroidal alkaloids from Sarcococca saligna [J].

Atta-ur-Rahman ;

Anjum, S ;

Farooq, A ;

Khan, MR ;

Parveen, Z ;

Choudhary, MI .

JOURNAL OF NATURAL PRODUCTS, 1998, 61 (02) :202-206

[2]

Atta-Ur-Rahman, 1998, NAT PROD LETT, V11, P81

[3] Phytochemical studies on steroidal alkaloids of Sarcococca saligna [J].

Atta-ur-Rahman ;

Anjum, S ;

Farooq, A ;

Khan, MR ;

Choudhary, MI .

NATURAL PRODUCT LETTERS, 1998, 11 (04) :297-304

[4] Steroidal alkaloids from Sarcococca saligna [J].

AttaurRahman ;

Khan, MR ;

Choudhary, MI ;

Iqbal, MZ .

PHYTOCHEMISTRY, 1997, 45 (04) :861-864

[5]

ATTAURRAHMAN, 1989, 1 2 DIMENSIONAL NMR

[6]

BODZKIEWICZ H, 1964, STRUCTURE ELUCIDATIO, V2, P5

[7] Alkaloids of Sarcococca saligna [J].

Naeem, I ;

Khan, N ;

Choudhary, MI ;

AttaurRahman .

PHYTOCHEMISTRY, 1996, 43 (04) :903-906

[8]

Nasir E.S., 1972, FLORA W PAKISTAN, P457

[9]

QUI M, 1994, ZHIWU YANJIU, V16, P286

[10] Two new pregnane-type steroidal alkaloids from Sarcococca saligna [J].

Rahman, AU ;

Anjum, S ;

Farooq, A ;

Khan, MR ;

Choudhary, MI .

PHYTOCHEMISTRY, 1997, 46 (04) :771-775

← 1 2 →