A key role of the basal ganglia in pain and analgesia - insights gained through human functional imaging

被引:250
作者
Borsook, David [1 ]
Upadhyay, Jaymin [1 ]
Chudler, Eric H. [2 ]
Becerra, Lino [1 ]
机构
[1] Harvard Univ, Sch Med, PAIN Grp, Belmont, MA 02478 USA
[2] Univ Washington, Dept Anesthesiol, Seattle, WA 98195 USA
来源
MOLECULAR PAIN | 2010年 / 6卷
关键词
POSITRON-EMISSION-TOMOGRAPHY; ANTERIOR CINGULATE CORTEX; CENTRAL-NERVOUS-SYSTEM; STRIATAL DOPAMINE RELEASE; NOXIOUS THERMAL STIMULI; HUMAN BRAIN ACTIVITY; D2; RECEPTOR-BINDING; CHRONIC BACK-PAIN; PARKINSONS-DISEASE; NUCLEUS-ACCUMBENS;
D O I
10.1186/1744-8069-6-27
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The basal ganglia (BG) are composed of several nuclei involved in neural processing related to the execution of motor, cognitive and emotional activities. Preclinical and clinical data have implicated a role for these structures in pain processing. Recently neuroimaging has added important information on BG activation in conditions of acute pain, chronic pain and as a result of drug effects. Our current understanding of alterations in cortical and sub-cortical regions in pain suggests that the BG are uniquely involved in thalamo-cortico-BG loops to integrate many aspects of pain. These include the integration of motor, emotional, autonomic and cognitive responses to pain.
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页数:17
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