Neuronal migration defects of the cerebral cortex: a destination debacle

被引：18

作者：

Uher, BF

Golden, JA

机构：

[1] Childrens Hosp Philadelphia, Dept Pathol, Abramson Res Ctr, Philadelphia, PA 19104 USA

[2] Univ Penn, Sch Med, Cell & Mol Biol Program, Philadelphia, PA 19104 USA

[3] Univ Penn, Sch Med, Dept Pathol, Philadelphia, PA 19104 USA

来源：

CLINICAL GENETICS | 2000年 / 58卷 / 01期

关键词：

cell migration; cerebral cortical development; heterotopia; lissencephaly;

D O I：

10.1034/j.1399-0004.2000.580103.x

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Disruptions in neuronal migration have been postulated as the basis for many cerebral malformations including lissencephaly, cortical heterotopia, and double cortex. Recently, the genetic basis for some of these disorders has been identified. In this review, we highlight recent advances in our understanding of the molecular mechanisms of neuronal migration and its relationship to cerebral cortical development and neuronal migration disorders. This has allowed us to begin categorizing specific malformations based on their molecular etiology.

引用

页码：16 / 24

页数：9

共 87 条

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