Apoptosis: Mitochondrial membrane permeabilization - The (W)hole story?

被引：146

作者：

Zamzami, N ^{[1
]}

Kroemer, G ^{[1
]}

机构：

[1] Inst Gustave Roussy, CNRS, UMR 1599, F-94805 Villejuif, France

来源：

CURRENT BIOLOGY | 2003年 / 13卷 / 02期

关键词：

D O I：

10.1016/S0960-9822(02)01433-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

One critical step of apoptosis is the release of mitochondrial proteins through the outer mitochondrial membrane. Recent work shows that two pro-apoptotic Bcl-2 family proteins, Bax and Bid, as well as the mitochondrion-specific lipid cardiolipin may cooperate in chemically defined liposomes to generate a protein-permeable conduit, relaunching the debate an the identity of the pore responsible for mitochondrial membrane permeabilization during apoptosis.

引用

页码：R71 / R73

页数：3

共 20 条

[11] Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria [J].

Narita, M ;

Shimizu, S ;

Ito, T ;

Chittenden, T ;

Lutz, RJ ;

Matsuda, H ;

Tsujimoto, Y .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (25) :14681-14686

[12] Cytochrome c release from mitochondria proceeds by a two-step process [J].

Ott, M ;

Robertson, JD ;

Gogvadze, V ;

Zhivotovsky, B ;

Orrenius, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (03) :1259-1263

[13] Mass spectrometric identification of proteins released from mitochondria undergoing permeability transition [J].

Patterson, SD ;

Spahr, CS ;

Daugas, E ;

Susin, SA ;

Irinopoulou, T ;

Koehler, C ;

Kroemer, G .

CELL DEATH AND DIFFERENTIATION, 2000, 7 (02) :137-144

[14] Bid induces cytochrome c-impermeable Bax channels in liposomes [J].

Roucou, X ;

Rostovtseva, T ;

Montessuit, S ;

Martinou, JC ;

Antonsson, B .

BIOCHEMICAL JOURNAL, 2002, 363 :547-552

[15]

ROUCOU X, 2002, IN PRESS BIOCH J, P23

[16] BAX-dependent transport of cytochrome c reconstituted in pure liposomes [J].

Saito, M ;

Korsmeyer, SJ ;

Schlesinger, PH .

NATURE CELL BIOLOGY, 2000, 2 (08) :553-555

[17] A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis [J].

Scorrano, L ;

Ashiya, M ;

Buttle, K ;

Weiler, S ;

Oakes, SA ;

Mannella, CA ;

Korsmeyer, SJ .

DEVELOPMENTAL CELL, 2002, 2 (01) :55-67

[18] Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC [J].

Shimizu, S ;

Narita, M ;

Tsujimoto, Y .

NATURE, 1999, 399 (6735) :483-487

[19] Proapoptotic BAX and BAK: A requisite gateway to mitochondrial dysfunction and death [J].

Wei, MC ;

Zong, WX ;

Cheng, EHY ;

Lindsten, T ;

Panoutsakopoulou, V ;

Ross, AJ ;

Roth, KA ;

MacCregor, GR ;

Thompson, CB ;

Korsmeyer, SJ .

SCIENCE, 2001, 292 (5517) :727-730

[20] Bid acts on the permeability transition pore complex to induce apoptosis [J].

Zamzami, N ;

El Hamel, C ;

Maisse, C ;

Brenner, C ;

Muñoz-Pinedo, C ;

Belzacq, AS ;

Costantini, P ;

Vieira, H ;

Loeffler, M ;

Molle, G ;

Kroemer, G .

ONCOGENE, 2000, 19 (54) :6342-6350

← 1 2 →