Nickel-Catalyzed Direct C-H Arylation and Alkenylation of Heteroarenes with Organosilicon Reagents

被引：250

作者：

Hachiya, Hitoshi ^{[1
]}

Hirano, Koji ^{[1
]}

Satoh, Tetsuya ^{[1
]}

Miura, Masahiro ^{[1
]}

机构：

[1] Osaka Univ, Dept Appl Chem, Fac Engn, Suita, Osaka 5650871, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 12期

关键词：

alkenylation; arylation; heterocycles; nickel; silanes; CROSS-COUPLING REACTIONS; MEDIATED DIRECT ARYLATION; ARYL BOND FORMATION; CARBON-HYDROGEN; REGIOSELECTIVE ARYLATION; DIRECT ALKYNYLATION; ARYLBORONIC ACIDS; AROMATIC KETONES; ROOM-TEMPERATURE; SILYL MIGRATION;

D O I：

10.1002/anie.200906996

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

"Chemical Equation Presented" Breaking the Si-lence: The direct crosscoupling of heteroarenes with aryl- or alkenylsilanes proceeds efficiently, in the presence of a nickel catalyst, to create a wide range of aryl- and alkenyl-heteroaryl bonds efficiently (see scheme; DMAc= N.N-dimethylacetamide, bpy = 2,2′-bipyridine). This catalysis represents a new avenue for using organosilanes in the catalytic C-H functionalization chemistry. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：2202 / 2205

页数：4

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