Can patients with chronic neuropathic pain be cured by acute administration of the NMDA receptor antagonist amantadine?

被引:49
作者
Eisenberg, E
Pud, D
机构
[1] Rambam Med Ctr, Pain Relief Unit, IL-31096 Haifa, Israel
[2] Univ Haifa, Ch Spenser Dept Nursing, IL-31999 Haifa, Israel
[3] Technion Israel Inst Technol, Rappaport Fac Med, IL-32000 Haifa, Israel
关键词
amantadine; N-methyl-D-aspartate receptor; neuropathic pain; 'wind-up' phenomenon;
D O I
10.1016/S0304-3959(97)00198-X
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
The treatment of neuropathic pain remains a challenge as it rarely leads to long-term relief of symptoms. We report three patients with chronic neuropathic pain, in whom acute administration of the N-methyl-D-aspartate (NMDA) receptor antagonist amantadine resulted in complete resolution of symptoms, presumably due to termination the central 'wind-up' phenomenon. (C) 1998 International Association for the Study of Pain. Published by Elsevier Science B.V.
引用
收藏
页码:337 / 339
页数:3
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