Bacterial resistance to vancomycin: Five genes and one missing hydrogen bond tell the story

被引：346

作者：

Walsh, CT

Fisher, SL

Park, IS

Prahalad, M

Wu, Z

机构：

[1] Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston

来源：

CHEMISTRY & BIOLOGY | 1996年 / 3卷 / 01期

关键词：

D O I：

10.1016/S1074-5521(96)90079-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A plasmid-borne transposon encodes enzymes and regulator proteins that confer resistance of enterococcal bacteria to the antibiotic vancomycin. Purification and characterization of individual proteins encoded by this operon has helped to elucidate the molecular basis of vancomycin resistance. This new understanding provides opportunities for intervention to reverse resistance.

引用

收藏

页码：21 / 28

页数：8

相关论文

共 32 条

[1] PROTEIN HISTIDINE KINASES AND SIGNAL-TRANSDUCTION IN PROKARYOTES AND EUKARYOTES [J].

ALEX, LA ;

SIMON, MI .

TRENDS IN GENETICS, 1994, 10 (04) :133-138

[2]

ALLEN NE, 1992, FEMS MICROBIOL LETT, V98, P109

[3] THE VANS-VANR 2-COMPONENT REGULATORY SYSTEM CONTROLS SYNTHESIS OF DEPSIPEPTIDE PEPTIDOGLYCAN PRECURSORS IN ENTEROCOCCUS-FAECIUM BM4147 [J].

ARTHUR, M ;

MOLINAS, C ;

COURVALIN, P .

JOURNAL OF BACTERIOLOGY, 1992, 174 (08) :2582-2591

[4] GENETICS AND MECHANISMS OF GLYCOPEPTIDE RESISTANCE IN ENTEROCOCCI [J].

ARTHUR, M ;

COURVALIN, P .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1993, 37 (08) :1563-1571

[5] THE STRUCTURE AND MODE OF ACTION OF GLYCOPEPTIDE ANTIBIOTICS OF THE VANCOMYCIN GROUP [J].

BARNA, JCJ ;

WILLIAMS, DH .

ANNUAL REVIEW OF MICROBIOLOGY, 1984, 38 :339-357

[6]

Barrett J. F., 1995, ANNU REP MED CHEM, V30, P111, DOI 10.1016/s0065-7743(08)60925-2

[7] MODIFICATION OF PEPTIDOGLYCAN PRECURSORS IS A COMMON FEATURE OF THE LOW-LEVEL VANCOMYCIN-RESISTANT VANB-TYPE ENTEROCOCCUS D366 AND OF THE NATURALLY GLYCOPEPTIDE-RESISTANT SPECIES LACTOBACILLUS-CASEI, PEDIOCOCCUS-PENTOSACEUS, LEUCONOSTOC-MESENTEROIDES, AND ENTEROCOCCUS-GALLINARUM [J].

BILLOTKLEIN, D ;

GUTMANN, L ;

SABLE, S ;

GUITTET, E ;

VANHEIJENOORT, J .

JOURNAL OF BACTERIOLOGY, 1994, 176 (08) :2398-2405

[8] ANALYSIS OF PEPTIDOGLYCAN PRECURSORS IN VANCOMYCIN-RESISTANT ENTEROCOCCI [J].

BILLOTKLEIN, D ;

GUTMANN, L ;

COLLATZ, E ;

VANHEIJENOORT, J .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1992, 36 (07) :1487-1490

[9] IDENTIFICATION OF VANCOMYCIN RESISTANCE PROTEIN VANA AS A D-ALANINE - D-ALANINE LIGASE OF ALTERED SUBSTRATE-SPECIFICITY [J].

BUGG, TDH ;

DUTKAMALEN, S ;

ARTHUR, M ;

COURVALIN, P ;

WALSH, CT .

BIOCHEMISTRY, 1991, 30 (08) :2017-2021

[10] MOLECULAR-BASIS FOR VANCOMYCIN RESISTANCE IN ENTEROCOCCUS-FAECIUM BM4147 - BIOSYNTHESIS OF A DEPSIPEPTIDE PEPTIDOGLYCAN PRECURSOR BY VANCOMYCIN RESISTANCE PROTEINS VANH AND VANA [J].

BUGG, TDH ;

WRIGHT, GD ;

DUTKAMALEN, S ;

ARTHUR, M ;

COURVALIN, P ;

WALSH, CT .

BIOCHEMISTRY, 1991, 30 (43) :10408-10415

← 1 2 3 4 →