Human embryonic stem cells as a model for early human development

被引：57

作者：

Dvash, T ^{[1
]}

Benvenisty, N ^{[1
]}

机构：

[1] Hebrew Univ Jerusalem, Alexander Silberman Inst Life Sci, Dept Genet, IL-91904 Jerusalem, Israel

来源：

BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY | 2004年 / 18卷 / 06期

关键词：

differentiation; embryogenesis; human development; organogenesis; pluripotency; stem cells;

D O I：

10.1016/j.bpobgyn.2004.06.005

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Although, the study of human development-from fertilized egg to mature embryo-is extremely important, the early differentiation of human tissues remains an enigma. Moreover, the relatively high percentage of unexplained pregnancy loss-a major concern of human embryologists and gynaecologists-emphasizes the need for an appropriate model for studying early human development. The availability of human pluripotent stem cells might allow us to study previously inaccessible basic processes that occur during human embryogenesis, such as gastrulation and organogenesis.

引用

页码：929 / 940

页数：12

共 51 条

[11] A molecular view on pluripotent stem cells [J].

Eiges, R ;

Benvenisty, N .

FEBS LETTERS, 2002, 529 (01) :135-141

[12]

Elsea Sarah H, 2002, ILAR J, V43, P66

[13] ESTABLISHMENT IN CULTURE OF PLURIPOTENTIAL CELLS FROM MOUSE EMBRYOS [J].

EVANS, MJ ;

KAUFMAN, MH .

NATURE, 1981, 292 (5819) :154-156

[14] Mammalian neural stem cells [J].

Gage, FH .

SCIENCE, 2000, 287 (5457) :1433-1438

[15] Integration and differentiation of human embryonic stem cells transplanted to the chick embryo [J].

Goldstein, RS ;

Drukker, M ;

Reubinoff, BE ;

Benvenisty, N .

DEVELOPMENTAL DYNAMICS, 2002, 225 (01) :80-86

[16] Human embryonic stem cells develop into multiple types of cardiac myocytes - Action potential characterization [J].

He, JQ ;

Ma, Y ;

Lee, Y ;

Thomson, JA ;

Kamp, TJ .

CIRCULATION RESEARCH, 2003, 93 (01) :32-39

[17] Differentiation of human embryonic stem cells into embryoid bodies comprising the three embryonic germ layers [J].

Itskovitz-Eldor, J ;

Schuldiner, M ;

Karsenti, D ;

Eden, A ;

Yanuka, O ;

Amit, M ;

Soreq, H ;

Benvenisty, N .

MOLECULAR MEDICINE, 2000, 6 (02) :88-95

[18] Hematopoietic colony-forming cells derived from human embryonic stem cells [J].

Kaufman, DS ;

Hanson, ET ;

Lewis, RL ;

Auerbach, R ;

Thomson, JA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (19) :10716-10721

[19] High-resolution electrophysiological assessment of human embryonic stem cell-derived cardiomyocytes - A novel in vitro model for the study of conduction [J].

Kehat, I ;

Gepstein, A ;

Spira, A ;

Itskovitz-Eldor, J ;

Gepstein, L .

CIRCULATION RESEARCH, 2002, 91 (08) :659-661

[20] Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes [J].

Kehat, I ;

Kenyagin-Karsenti, D ;

Snir, M ;

Segev, H ;

Amit, M ;

Gepstein, A ;

Livne, E ;

Binah, O ;

Itskovitz-Eldor, J ;

Gepstein, L .

JOURNAL OF CLINICAL INVESTIGATION, 2001, 108 (03) :407-414

← 1 2 3 4 5 6 →