Resolution of psoriasis after allogeneic bone marrow transplantation for chronic myelogenous leukemia: late complications of therapy

被引：27

作者：

Adkins, DR ^{[1
]}

Abidi, MH ^{[1
]}

Brown, RA ^{[1
]}

Khoury, H ^{[1
]}

Goodnough, LT ^{[1
]}

Vij, R ^{[1
]}

Westervelt, P ^{[1
]}

DiPersio, JF ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Internal Med, Div Bone Marrow Transplantat & Stem Cell Biol, St Louis, MO 63110 USA

来源：

BONE MARROW TRANSPLANTATION | 2000年 / 26卷 / 11期

关键词：

autoimmunity; psoriasis; bone marrow transplantation;

D O I：

10.1038/sj.bmt.1702703

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Treatment of autoimmune disease with bone marrow transplantation (BMT) is under investigation. A few reports of patients undergoing allogeneic BMT for malignant conditions observed the resolution of psoriasis after BMT, with minimal late morbidity. We describe a patient with chronic myelogenous leukemia (CML) whose psoriasis resolved completely after allogeneic BMT. However, the patient's course was complicated by extensive chronic graft-versus-host disease (GVHD), recurrent serious infections, poor performance status and quality of life, and severe disability. The patient died 887 days post transplant due to infectious complications. The potential benefits and risks of treatment of autoimmune diseases with allogeneic BMT are discussed.

引用

页码：1239 / 1241

页数：3

共 11 条

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