Expression and immunolocalization of multidrug resistance protein 2 in rabbit small intestine

被引：37

作者：

Van Aubel, RAMH

Hartog, A

Bindels, RJM

Van Os, CH

Russel, FGM

机构：

[1] Catholic Univ Nijmegen, UMC St Radboud, Dept Pharmacol & Toxicol, NL-6500 HB Nijmegen, Netherlands

[2] Catholic Univ Nijmegen, UMC St Radboud, Dept Cell Physiol, NL-6500 HB Nijmegen, Netherlands

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2000年 / 400卷 / 2-3期

关键词：

multidrug resistance protein; MRP2 (multidrug resistance protein 2); intestine;

D O I：

10.1016/S0014-2999(00)00391-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Multidrug resistance protein 2 (MRP2) is an ATP-dependent transporter of anionic drugs and conjugates. It functions as an efflux pump in the apical membranes of liver and kidney cells, but its membrane localization in small intestine has not yet been defined. The present study demonstrates exclusive localization of Mrp2 to the brush-border (apical) membrane of villi, decreasing in intensity from the villus tip to the crypts. In immunoblot analysis of crude membranes of various rabbit tissues, Mrp2 was only found in small intestine, kidney and liver. These results are in-line with the supposed function of Mrp2 in drug excretion. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：195 / 198

页数：4